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At a glance

Levofloxacin is an antibiotic used in the treatment of bacterial infections. It treats infections of the urinary tract, nose, throat, skin, soft tissues, and lungs (pneumonia).

Indications
  • Community-acquired pneumonia
  • Nosocomial pneumonia
  • Acute bacterial sinusitis
  • Acute bacterial exacerbation of chronic bronchitis
  • Skin and soft tissue infections
  • Chronic bacterial prostatitis
  • Complicated and uncomplicated urinary tract infections
  • Acute pyelonephritis
  • Inhalational anthrax (post-exposure prophylaxis)
  • Plague (pneumonic and septicemic)
Pharmacology

Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase to prevent bacterial DNA replication, transcription, repair, and recombination.

Dosage

Adult Dose (Oral/IV):

  • Community pneumonia: 500 mg daily 7-14 days OR 750 mg daily 5 days
  • Nosocomial pneumonia: 750 mg daily 7-14 days
  • Acute sinusitis: 500 mg daily 10-14 days OR 750 mg daily 5 days
  • Chronic bronchitis: 500 mg daily 7 days
  • Skin infections (complicated): 750 mg daily 7-14 days; (uncomplicated): 500 mg daily 7-10 days
  • Prostatitis: 500 mg daily 28 days
  • Complicated UTI/Pyelonephritis: 250 mg daily 10 days OR 750 mg daily 5 days
  • Uncomplicated UTI: 250 mg daily 3 days
Side effects

Common Side Effects:

  • Headache
  • Dizziness
  • Nausea
  • Constipation
  • Diarrhea
  • Tendon pain or swelling
  • Numbness or tingling sensation
Use in pregnancy

Use in Pregnancy: Levofloxacin is unsafe during pregnancy; definite evidence of risk to the fetus. Use only in life-threatening situations with doctor's advice.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution when driving or activities requiring concentration (may cause dizziness or drowsiness)
  • Discontinue if tendon pain, swelling, or rupture signs occur
  • Inform doctor if diarrhea persists or blood in stools
  • Consult doctor during pregnancy and lactation
Overdose effects

No specific overdose information available; symptomatic and supportive measures should be employed.

Storage conditions

Store in a dry place away from light and heat; keep out of reach of children.

Levofloxacin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.