Gensulin M30 Cartidge100IU/ml

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus (not adequately controlled by diet and oral hypoglycemic agents)
• Diabetic ketoacidosis
• Hyperosmolar non-ketotic syndrome
• Gestational diabetes

Adult Dose (Subcutaneous):

• Type 1 Diabetes: 0.5-1 unit/kg/day in divided doses; prepubertal children: 0.7-1 unit/kg/day
• Type 2 Diabetes: Starting: 0.3-0.6 units/kg/day; titrate accordingly
• 50-75% of total daily dose given as intermediate- or long-acting insulin
• Morning: 2/3 of daily insulin (Regular:NPH = 1:2); Evening: 1/3 (Regular:NPH = 1:1)

Child Dose (Type 1): Ketones moderate or less: 0.5 units/kg/day; Ketones large: 0.7 units/kg/day

Side Effects:

• Hypoglycemia
• Injection site reactions (redness, swelling, pain)
• Lipodystrophy
• Pruritus
• Rash
• Lipoatrophy
• Hypokalemia
• Blurred vision
• Insulin resistance
• Headache
• Influenza-like symptoms
• Dyspepsia
• Diarrhea
• Back pain
• Pharyngitis
• Angioneurotic edema

Precautions:

• Pregnancy (insulin requirements fall in 1st trimester, increase in 2nd and 3rd) and lactation
• Caution with decreased insulin requirements: Diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment
• Hypokalemia may occur
• Caution in renal and hepatic impairment (dosage requirements may be reduced)
• Caution with increased insulin requirements: Fever, hyperthyroidism, trauma, infection, surgery
• Not for IV or IM administration
• Do not use if clumps or solid white particles are present after mixing