৳ 6/unit
Pack: ৳ 6
৳ 6/unit
Pack: ৳ 6
At a glance
Candesartan Cilexetil + Hydrochlorothiazide is a combination medication used in the treatment of hypertension and congestive heart failure. Candesartan blocks angiotensin II receptors to dilate blood vessels, and Hydrochlorothiazide acts as a diuretic to remove excess water and salt from the body, lowering blood pressure.
Indications
- Hypertension
- Congestive heart failure
Pharmacology
Candesartan Cilexetil is a prodrug that is converted to active Candesartan after absorption. Candesartan blocks AT1 receptors, inhibiting the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Hydrochlorothiazide inhibits Na⁺ and Cl⁻ reabsorption in distal tubules, increasing excretion of Na⁺, water, and K⁺ and H⁺ ions, reducing plasma volume and lowering blood pressure. Coadministration of Candesartan tends to reverse the potassium loss associated with Hydrochlorothiazide.
Dosage
Adults: 1 tablet once daily (Candesartan 16-32 mg/HCTZ 12.5-25 mg).
Elderly: No dosage adjustment needed.
Hepatic impairment: Mild-moderate: Dose titration recommended; Severe hepatic impairment and/or cholestasis: Do not use.
Renal impairment: Mild-moderate (CrCl 30-80 mL/min/1.73 m²): Dose titration recommended; Severe (CrCl <30 mL/min/1.73 m²): Do not use.
Children: Safety and efficacy have not been established.
Side effects
Common side effects: Headache, dizziness, fatigue, nausea, diarrhea, abdominal pain, taste change, decreased blood pressure, increased uric acid, electrolyte imbalance, glucose intolerance, increased blood lipids.
Upper respiratory tract infection, back pain, influenza-like symptoms (side effects are generally mild and transient; overall incidence comparable to placebo).
Serious (rare): Angioedema, hyperkalemia, renal failure, hyponatremia.
Use in pregnancy
Unsafe during pregnancy (Category D). Definite evidence of risk to the developing baby. Discontinue as soon as pregnancy is detected. May be used in life-threatening situations if benefits outweigh risks.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause dizziness; rise slowly from sitting or lying position.
- Drink plenty of fluids to prevent dehydration; inform your doctor if you develop extreme thirst, very dry mouth, or muscle weakness.
- Do not use potassium supplements or salt substitutes without your doctor's advice (risk of hyperkalemia).
- Not recommended during pregnancy and lactation (Category D).
- Do not stop suddenly (may cause rebound hypertension).
- Avoid alcohol consumption (increases risk of hypotension and dizziness).
- Diabetic patients should monitor blood glucose regularly (may cause glucose intolerance).
Overdose effects
Overdose symptoms: Severe hypotension, dizziness, tachycardia, electrolyte imbalance (hypokalemia, hyponatremia), renal failure. Treatment: Gastric lavage, IV fluids, vasopressors, electrolyte monitoring. Consult your doctor immediately if overdose is suspected.
Storage conditions
Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.