osudhkosh
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At a glance

Oral alpha-glucosidase inhibitor that improves postprandial glycemic control in adults with type 2 diabetes mellitus.

Indications

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Pharmacology

Acarbose reversibly inhibits intestinal alpha-glucosidases and pancreatic alpha-amylase, delaying the digestion and absorption of complex carbohydrates, thereby reducing postprandial blood glucose spikes without increasing insulin secretion.

Dosage

Initial: 25 mg orally three times daily with the first bite of each main meal. Maintenance: Titrate at 4-8 week intervals up to 50 mg to 100 mg three times daily based on postprandial glucose and tolerance.

Side effects

Flatulence, diarrhea, abdominal discomfort, abdominal pain, and nausea, which usually diminish over time as therapy continues.

Use in pregnancy

Pregnancy Category B. Safety in pregnant women has not been established; use only if clearly needed.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings

Does not cause hypoglycemia when used as monotherapy. However, when combined with sulfonylureas or insulin, hypoglycemia may occur. Mild to moderate hypoglycemia must be treated with oral dextrose (glucose) rather than sucrose.

Overdose effects

Overdose does not cause hypoglycemia but increases flatulence, diarrhea, and abdominal discomfort. Avoid carbohydrate-containing meals/drinks for 4–6 hours.

Storage conditions

Store below 25°C. Protect from moisture. Keep out of reach of children.

Acarbose — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.