৳ 35/unit
Pack: ৳ 350
৳ 35/unit
Pack: ৳ 350
At a glance
Saxagliptin is a DPP-4 inhibitor used for the treatment of type 2 diabetes mellitus. It slows the inactivation of incretin hormones, increasing insulin secretion and reducing glucose production.
Indications
- Type 2 diabetes mellitus (as an adjunct to diet and exercise)
Pharmacology
Saxagliptin competitively inhibits DPP-4 enzyme, slowing the breakdown of incretin hormones (GLP-1 and GIP). This increases glucose-dependent insulin secretion from the pancreas and reduces hepatic glucose production, lowering both fasting and postprandial blood glucose levels.
Dosage
Adult Dose (Oral):
- Recommended: 2.5 mg or 5 mg once daily
- With strong CYP3A4/5 inhibitors: Do not exceed 2.5 mg/day
- Renal impairment (CrCl <50): 2.5 mg/day (post-dialysis)
Side effects
Common Side Effects (>5%):
- Upper respiratory tract infection
- Urinary tract infection
- Headache
- Hypoglycemia (with sulfonylurea)
- Peripheral edema (with TZD)
Use in pregnancy
Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Not effective in type 1 diabetes or diabetic ketoacidosis
- Be aware of hypoglycemia symptoms
- Caution in severe liver disease
- Avoid alcohol consumption
Overdose effects
Overdose up to 400 mg/day (80 times MRHD) showed no dose-related adverse reactions; 23% removed by hemodialysis; provide symptomatic treatment.
Storage conditions
Store at 20-25°C, protected from light and moisture; keep out of reach of children.