osudhkosh
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Company•Healthcare Pharmaceuticals Ltd.

Hepacare 400

Rx
Generic: Sofosbuvir

৳ 1/unit

Pack: ৳ 1

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At a glance

Sofosbuvir is an HCV NS5B polymerase inhibitor used in combination with other antiviral agents for the treatment of chronic hepatitis C infection. It works by inhibiting viral replication.

Indications
  • Chronic hepatitis C (HCV) infection (genotypes 1, 2, 3, 4)
Pharmacology

Sofosbuvir is a nucleotide prodrug that is converted intracellularly to the active metabolite GS-461203. This active metabolite binds to the GDD active site of HCV NS5B RNA-dependent RNA polymerase, terminates viral RNA chain elongation, and prevents HCV replication.

Dosage

Adult Dose (Oral):

  • 400 mg tablet once daily (with or without food)
  • Genotype 1 or 4: Sofosbuvir + Peginterferon alfa + Ribavirin (12 weeks)
  • Genotype 2: Sofosbuvir + Ribavirin (12 weeks)
  • Genotype 3: Sofosbuvir + Ribavirin (24 weeks)
  • Hepatocellular carcinoma (awaiting liver transplant): Up to 48 weeks
Side effects

Common Side Effects (≥20%):

  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Anemia
  • Pruritus, asthenia, rash
  • Decreased appetite, chills, pyrexia
  • Diarrhea, neutropenia, myalgia
Use in pregnancy

Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; combination with ribavirin is contraindicated; consult your doctor.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • No dose recommendation for severe renal impairment or ESRD
  • Serious bradycardia with amiodarone co-administration (caution)
  • Caution in pregnancy and lactation (contraindicated with ribavirin combination)
Overdose effects

Highest dose: 1200 mg single dose; no specific antidote; monitor vital signs and provide supportive care.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Sofosbuvir — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.