৳ 5/unit
Pack: ৳ 50
৳ 5/unit
Pack: ৳ 50
At a glance
Trihexyphenidyl Hydrochloride is used with other medicines to treat Parkinson's disease and severe movement side effects caused by certain drugs (drug-induced movement disorder).
Indications
- Parkinson's disease
- Drug-induced abnormal movements
- Drug-induced extrapyramidal symptoms
Pharmacology
Trihexyphenidyl is a non-selective muscarinic acetylcholine receptor antagonist but binds with higher affinity to the M1 subtype. It demonstrates higher affinity for central muscarinic receptors and lower affinity for peripheral ones. It may modify nicotinic acetylcholine receptor neurotransmission, leading to enhanced dopamine release in the striatum.
Dosage
Adult Dose (Oral):
- Drug-induced extrapyramidal symptoms: 5-15 mg/day divided every 6-8 hours
- Parkinson disease: Initially 1 mg daily, gradually increased at 3-5 day intervals by 2 mg increments until 6-10 mg daily in 3-4 divided doses; maintenance 5-15 mg/day
- Parkinsonism: 5-15 mg/day divided every 6-8 hours
- Elderly: May require lower doses
Side effects
Common Side Effects:
- Dry mouth
- Nausea
- Vomiting
- Constipation
- Blurred vision
- Dizziness
- Upset stomach
- Headache
- Difficulty in urination
- Nervousness
- Tachycardia
- Dilation of pupil
- Increased intraocular pressure
- Confusion
- Memory impairment
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- Dry mouth may occur; frequent mouth rinses, good oral hygiene, increased water intake, sugarless candy may help
- May cause dry eyes; avoid contact lenses
- Monitoring of intraocular pressure required
- Inform doctor if glaucoma or trouble passing urine
- Do not stop suddenly; may cause NMS
- Caution in hot weather; risk of hyperthermia
Overdose effects
Symptoms: Central anticholinergic syndrome (delirium, hallucinations, tachycardia, dry skin, urinary retention, seizures, coma).
Treatment: Gastric lavage, supportive; diazepam or short-acting barbiturate; phenothiazines contraindicated.
Storage conditions
Store at temperature not exceeding 30°C in a dry place. Protect from light.