Hi-Vol IV Infusion 500ml6% + .09%

• Hypovolemia (reduced blood volume) - treatment and prophylaxis in adults and children

Adult Dose (IV Infusion):

• Most commonly used: up to 33 ml/kg per day
• Limited experience: 33-50 ml/kg/day
• Initial 10-20 ml should be infused slowly (monitor for anaphylactoid reactions)

Pediatric Dose (IV Infusion):

• Average: 16±9 ml/kg per day
• Dosage should be adapted to individual patient colloid needs, disease state, hemodynamic and hydration status

Most Common Reactions (incidence >1%):

• Pruritus (itching)
• Elevated serum amylase
• Hemodilution

Anaphylactoid/Hypersensitivity Reactions: Influenza-like symptoms, bradycardia, tachycardia, bronchospasm, non-cardiac pulmonary edema

Precautions:

• Monitor for anaphylactoid reactions; discontinue immediately if reaction occurs
• Avoid use in pre-existing renal dysfunction; discontinue at first sign of renal injury
• Monitor coagulation status in open heart surgery patients; discontinue at first sign of coagulopathy
• Avoid fluid overload; adjust dosage in cardiac or renal dysfunction
• In severe dehydration, give crystalloid solution first
• Monitor fluid balance, serum electrolytes, kidney function, acid-base balance, coagulation parameters during prolonged therapy
• Monitor liver function