HMG IM/SC Injection150IU/Vial

• Female infertility: hypo- or normogonadotropic ovarian insufficiency - stimulation of follicle growth
• Male infertility: hypo- or normogonadotropic hypogonadism - in combination with HCG to stimulate spermatogenesis
• In vitro fertilisation (IVF) procedures and other assisted conception techniques

Female Dose (IM/SC):

• Ovulation induction: 75-150 IU FSH daily, adjust gradually until adequate response
• After pre-ovulatory estradiol level achieved, HCG 5,000-10,000 IU (1-2 days after last HMG dose)
• Start within first 7 days of menstrual cycle

Male Dose (IM/SC):

• First treat with HCG 2 X 5,000 IU/week (until testosterone normalizes)
• Then HMG 75-150 IU FSH 2-3 times weekly (for several months)

IVF/Assisted Conception:

• 75-300 IU FSH daily (start on day 2 or 3 of cycle)

* Use as directed by the registered physician

Common Side Effects:

• Ovarian hyperstimulation
• Risk of multiple pregnancy and miscarriage
• Hypersensitivity and local reactions at injection site
• Nausea
• Vomiting
• Joint pain
• Fever
• In men: gynecomastia, acne, weight gain

Serious (Potentially Fatal): Rupture of ovarian cysts and intraperitoneal haemorrhage

Precautions:

• Hyperprolactinemia or tumors of the pituitary or hypothalamus
• Ovarian enlargement at risk of rupture
• Risk of multiple births
• Regular ultrasound and estradiol monitoring required during treatment
• If unintentional hyperstimulation occurs, discontinue treatment