Human Anti-Tetanus Immuno Globulin
250IU/mlRx৳ 2,500/unit
Pack: ৳ 2,500
৳ 2,500/unit
Pack: ৳ 2,500
At a glance
Tetanus (Human Anti-tetanus) Immunoglobulin is used for passive immunization against tetanus, particularly for post-exposure prophylaxis in patients with incomplete or uncertain immunization and for therapeutic treatment of tetanus.
Indications
- Tetanus prophylaxis (post-injury in patients with incomplete or uncertain immunization)
- Therapeutic treatment of tetanus
Pharmacology
Tetanus Immunoglobulin contains high-titer antibodies against tetanus toxoid that neutralize tetanus toxin. It provides immediate passive immunity, while adsorbed tetanus vaccine provides long-term active immunity.
Dosage
Adult Dose (IM):
- Post-exposure prophylaxis: 250 IU single dose
- High-risk cases (infected wounds, deep/contaminated wounds, burns, tissue necrosis): 500 IU
- Extensive burns: Second 250 IU dose after 36 hours
- Tetanus treatment: 3,000-6,000 IU (with other clinical procedures)
Pediatric Dose (IM):
- Post-exposure prophylaxis: 250 IU single dose
- High-risk cases: 500 IU
- Tetanus treatment: 3,000-6,000 IU
Side effects
Common Side Effects:
- Injection site reactions (pain, tenderness)
- Fever
- Angioneurotic edema
- Nephritic syndrome
- Anaphylactic shock (rare)
Use in pregnancy
Use in Pregnancy: Safety not established in controlled trials; long-term clinical experience suggests no harmful effects on pregnancy, fetus, or neonate; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in coagulation disorders or thrombocytopenia
- Not for IV administration
- Caution in pregnancy and lactation
- Caution in patients with IgA deficiency and antibodies to IgA
Overdose effects
No overdose information; excessive doses may increase allergic reaction risk; provide symptomatic treatment.
Storage conditions
Store at 2-8°C in a refrigerator; do not freeze; protect from light; keep out of reach of children.