Hypanil

• Hypertension (high blood pressure)
• Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Adult Dose (Oral):

• Hypertension: Initial: 50 mg/12.5 mg once daily; may increase to 100 mg/25 mg if needed
• Severe Hypertension: Starting dose: 50/12.5 once daily; may increase to 100/25 after 2-4 weeks if needed
• Hypertension with LVH: Initial: 50/12.5; may increase to 100/12.5, then 100/25 if needed; Max: 100/25 once daily
• Volume Depletion: Start with losartan 25 mg once daily
• Elderly: Initial dose 50/12.5; Max 100/25 should not be used as initial therapy

Renal Dose: CrCl >30 mL/min: No dosage adjustment; not recommended in severe renal impairment

Common Side Effects:

• Dizziness
• Nausea
• Taste change
• Upset stomach
• Diarrhea
• Headache
• Weakness
• Decreased blood pressure
• Glucose intolerance
• Increased blood uric acid
• Electrolyte imbalance

Others: Vertigo, angioedema, hyperkalemia, gastrointestinal disturbances, angina, palpitation, dyspnea, hepatitis, atrial fibrillation, syncope, pancreatitis, cough, erectile dysfunction, renal impairment

Precautions:

• Hydrochlorothiazide + Losartan may decrease alertness, affect vision or make you feel sleepy and dizzy; do not drive if these symptoms occur
• May cause dehydration; drink plenty of fluids; inform doctor if extreme thirst, very dry mouth or muscle weakness develops
• May cause dizziness; get up slowly when rising from a sitting or lying position
• Not safe during pregnancy and breastfeeding
• Angioedema: caution
• Periodic determination of serum electrolytes
• Hypokalemia may rarely develop; with severe cirrhosis or after prolonged therapy
• Renal impairment and symptomatic hypotension