৳ 9/unit
Pack: ৳ 9
৳ 9/unit
Pack: ৳ 9
At a glance
Potassium iodide is used for Grave's disease, iodine deficiency disorders, hyperthyroidism, thyroid storm, and to reduce vascularity of the thyroid gland before surgery.
Indications
- Grave's disease
- Iodine deficiency disorders
- Hyperthyroidism
- Thyroid storm
- Preoperative reduction of vascularity of the thyroid gland
- Radiation protection against radioactive iodine
- Wound and ulcer cleansing
Pharmacology
Potassium iodide participates in a complex series of reactions in the thyroid gland to produce thyroid hormones. When used for hyperthyroidism, it rapidly inhibits the release of thyroid hormones via a direct effect on the thyroid gland and inhibits the synthesis of thyroid hormones. Vascularity of the thyroid gland is reduced. In radiation emergencies, oral potassium iodide blocks thyroidal uptake of radioactive isotopes of iodine.
Dosage
Adult Dose (Oral):
- Preoperative reduction of thyroid vascularity: 50-250 mg (approx 1-5 drops of solution containing 1 g/ml) tid for 10-14 days before surgery
- Radiation protection against radioactive iodine: 100-150 mg 24 hr before procedure and daily for up to 10 days after
- Thyrotoxicosis: 500 mg every 4 hr (given 1 hr after an antithyroid agent)
- Iodine deficiency disorders: Iodised oil: 400 mg iodine once yearly; Pregnant: 200 mg iodine as single dose
Child Dose (Oral):
- Preoperative reduction of thyroid vascularity: 50-250 mg tid for 10-14 days before surgery
- Radiation protection: Birth-1 month: 16 mg; 1 month-3 years: 32 mg; 3-18 years: 65 mg
- Iodine deficiency disorders: Up to 1 year: 100 mg; 1-5 years: 200 mg; >6 years: 400 mg
Side effects
Side Effects:
- Hypersensitivity reactions (urticaria, angioedema, cutaneous haemorrhage, purpura, fever, arthralgia, lymphadenopathy, eosinophilia)
- Goitre
- Hypothyroidism
- Hyperthyroidism
- Iodism on prolonged use (metallic taste, increased salivation, swelling and inflammation of throat, swollen and irritated eyes, pulmonary oedema, nausea, vomiting, diarrhoea)
Potentially Fatal: Fatal periarteritis, ioderma
Use in pregnancy
Use in Pregnancy: Caution in pregnancy; iodine deficiency disorders: pregnant patient 200 mg iodine as single dose (oral) or 480 mg iodine each year (IM).
Precautions & warnings
Precautions:
- Caution in pregnancy and lactation
- Caution in hyperkalaemia, hyperthyroidism, myotonia congenita, renal function impairment, tuberculosis, hypocomplementemic vasculitis, goiter, autoimmune thyroid disease
- Children: Repeated administration not recommended in neonates (risk of hypothyroidism)
- Caution in acute bronchitis
Overdose effects
Overdose: High doses may cause iodism (metallic taste, increased salivation, throat swelling, nausea, vomiting, diarrhoea), goitre, hypothyroidism, hyperthyroidism; provide symptomatic treatment.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.