Imruza 25

Azathioprine belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by weakening your body’s immune system, so it does not attack the new organ. The amount of Azathioprine to be taken and how often you need to take it will depend on the type of transplant you have. Follow your doctor's instructions on this. You should take it along with food. Swallow it as a whole, do not crush, chew, break, or open them. Take the medicine regularly to get the most benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection. It has many potential side effects. The most common are loss of appetite, nausea and increased risk of bleeding. Because it suppresses your immune system, you may catch more infections than usual. There's also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use a protective cream. There is a long list of potential side effects. You should ask your doctor about them and what signs to look out for because some can be serious and need urgent medical attention. Azathioprine can cause birth defects and miscarriages so do not take it if you are pregnant, planning to become pregnant or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. Your doctor also needs to know what other medicines you are taking as there are many which interact with this medicine and affect the way it works. You will have regular tests to check for any changes in the number of your blood cells. Azathioprine is an immunosuppressant. It reduces the action of body's own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

• Prevention of organ rejection in transplant patients • Rheumatoid arthritis

Azathioprine is an imidazolyl derivative of mercaptopurine, which inhibits DNA, RNA and protein synthesis and antagonises purine synthesis. It also inhibits mitosis and interferes with cellular metabolism of susceptible organisms. Azathioprine inj should be converted to oral therapy as soon as the drug can be tolerated.

Adult Dose: Rheumatoid Arthritis 1 mg/kg/day PO initially in single daily dose or divided q12hr; may be increased by 0.5 mg/kg/day after 6-8 weeks, then by 0.5 mg/kg/day every 4 weeks; not to exceed 2.5 mg/kg/day Maintenance: Reduce daily dose by 0.5 mg/kg every 4 weeks until lowest effective dosage is reached Kidney Transplantation Prevention of transplant rejection 3-5 mg/kg/day PO initially on day of transplant or 3 days before transplant (rare) Maintenance: 1-3 mg/kg/day PO Auto-immune diseases 1-3 mg/kg/day. Hepatic Impairment Reduce dose. Child Dose: Juvenile Idiopathic Arthritis 1 mg/kg/day PO initially in single daily dose or divided q12hr; may be increased by 0.5 mg/kg/day after 6-8 weeks, then by 0.5 mg/kg/day every 4 weeks; not to exceed 2.5 mg/kg/day Maintenance: Reduce daily dose by 0.5 mg/kg every 4 weeks until lowest effective dosage is reached Renal Dose: Reduce dose.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azathioprine is to be taken with food.

Common: • Decreased white blood cell count • Increased bleeding tendency • Nausea • Infection • Loss of appetite

[CONSULT YOUR DOCTOR] It is not known whether Azathioprine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Your doctor has prescribed Azathioprine to stop the body from rejecting a transplanted organ (e.g. kidney, heart or liver). Azathioprine also relieves joint pain and inflammation in rheumatoid arthritis. You may have to take additional medications along with Azathioprine for better relief of symptoms. Avoid contact with people who have cold, flu or other contagious illness. Notify your doctor if you have any signs of infection such as a fever or sore throat. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Hypersensitivity; previous treatment with alkylating agents; pregnancy, lactation.

Increased risk of haematotoxicity with aminosalicylates, drugs that affect myelopoesis e.g. co-trimoxazole or trimethoprim. Increased risk of infections with intra-uterine devices and live vaccines. Increased risk of leucopenia with ACE inhibitors. Concurrent use may reduce the anticoagulant effect of vitamin K antagonists e.g. warfarin. Increased risk of myelosuppressive effects when used with drugs that inhibit TPMT (thiopurine methyltransferase) or xanthine oxidase e.g. olsalazine, allopurinol. Potentially Fatal: Increased risk of serious haematotoxicity or hepatotoxicity with leflunomide. Increased risk of bone marrow suppression with mycophenolate mofetil. Increased risk of infections and malignancies with efalizumab.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Azathioprine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Azathioprine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Azathioprine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Azathioprine should be used with caution in patients with kidney disease. Dose adjustment of Azathioprine may be needed. Please consult your doctor. Use of Azathioprine is not recommended in patients with serious kidney disease. [CAUTION] Azathioprine should be used with caution in patients with liver disease. Dose adjustment of Azathioprine may be needed. Please consult your doctor. Use of Azathioprine is not recommended in patients with severe liver disease. Regular monitoring of liver function tests is advisable while you are taking this medicine.

Mysthania gravis treatment and cure Sir m suffering from mysthania gravis from last 1.5 years though drooping of eyes have been controlled at intial level and i keep close track of tlc and heamoglobin taking 60 mg of gravitor along with a multivitamin supplements , wat is next course of action that i have to take or any other medicine for a while my dr. Had prescribed azoran (immuno suppresive agent) pl guide me u need long term azoran Is Azoran 50mg tablets used for treatment vitiligo. It is one of the medications for vitiligo depending upon the status of the disease ILD affected by Juvinle rheumatoid arthritis? After Lung transplant again may affected ILD because of arthritis? Yes ild can occur due to arthritis . Lung transplant is last procedure for uncontrollable disease. Medicines may control stmptoms Rheumatoid arthritis diseases attack Rheumatoid arthritis diseases tablet for this please consult rheumatologist for the same Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason? This is the test for rheumatoid arthritis Suffering from type 2 diabetes rheumatoid arthritis , asthma which medicine should I use Most of the diabetic drugs can be given in Rheumatoid arthritis and asthma patients however however steroids treatments is given many times in asthma and Rhumatoid arthritis should be given with very caution in diabetic patients if indicatedMost suitable some times are insulin injections I have joint pain in my rt wrist since 6 yrs. What are the possible reasons? It may be Tenosynovitis, or Rheumatoid arthritis or any other type of arthritis What is gatheya. What is it solution It is supposed to be Rheumatoid Arthritis