Instasia

• Minor dermal procedures
• Major dermal procedures
• Minor surgery on genital mucous membranes
• Pretreatment for infiltration anesthesia

Benzocaine, Butamben, and Tetracaine stabilize neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. This combination provides rapid onset and prolonged anesthetic effect.

Benzocaine and Butamben are ester-type local anesthetics, and Tetracaine is also an ester-type local anesthetic. They act on nerve endings at the application site to create temporary numbness.

Adults:

• Minor dermal procedure (local analgesia): Apply 2.5 g of cream over 20-25 cm² of skin surface for at least 1 hour.
• Major dermal procedure: Apply 2 g of cream per 10 cm² of skin surface for at least 2 hours.
• Male genital skin: Apply thick layer of cream (1 g/10 cm²) for 15 minutes; perform infiltration anesthesia immediately after removal.
• Female genital mucous membranes: Apply thick layer (5-10 g) of cream for 5-10 minutes.

Children (intact skin only):

• 0-3 months or <5 kg: Max 1 hour, 1 g per 10 cm² skin.
• 3-12 months & ≥5 kg: Max 4 hours, 2 g per 20 cm² skin.
• 1-6 years & >10 kg: Max 4 hours, 10 g per 100 cm² skin.
• 7-12 years & >20 kg: Max 4 hours, 20 g per 200 cm² skin.

• Paleness (37%)
• Erythema (30%)
• Burning sensation (17%)
• Edema (10%)
• Alterations in temperature sensations (7%)
• Itching (2%)
• CNS excitement or depression
• Lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness
• Sensations of hot, cold, or numbness
• Twitching, tremors, convulsions
• Bradycardia, hypotension, cardiovascular collapse
• Vomiting
• Purpuric or petechial reactions at application site, hyperpigmentation
• Redness, blistering (in neonates during circumcision)
• Tinnitus, blurred or double vision
• Allergic and anaphylactoid reactions (urticaria, angioedema, bronchospasm, shock)

Pregnancy Category B: Limited safety data during pregnancy. Use only if clearly needed and under medical supervision.

• Application to larger areas or for longer than recommended could result in sufficient absorption causing serious adverse reactions
• Avoid if allergic to amide-type local anesthetics
• Do not apply to open wounds or broken skin
• Avoid contact with eyes and mucous membranes
• Blistering may occur in neonates during circumcision

Overuse may cause systemic absorption and toxicity. Seek emergency medical attention if severe symptoms occur.

Store below 30°C, away from light and moisture. Keep out of reach of children.