Ipadox 100

• Respiratory tract infections (pneumonia, influenza, sinusitis, bronchitis, tonsillitis, tracheitis)
• Gastrointestinal tract infections (cholera, traveler's diarrhea, shigella dysentery, acute intestinal amebiasis)
• Chlamydial infections (lympho-granuloma venereum, psittacosis, trachoma)
• Sexually transmitted diseases (non-gonococcal urethritis, acute pelvic inflammatory disease, urethral and endocervical infections, gonorrhoea, syphilis, pyelonephritis, cystitis)
• Other infections (impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, Q-fever)
• Malaria prophylaxis (short-term travelers)
• Anthrax (post-exposure prophylaxis)
• Rickettsial infections (Rocky Mountain spotted fever, typhus fever, Q fever)

Doxycycline is a semisynthetic tetracycline antibiotic with broad spectrum activity. It is primarily a bacteriostatic antibiotic. Doxycycline binds to the 30S ribosomal subunit and inhibits bacterial protein synthesis. It is particularly active against Staphylococcus aureus and Nocardia. It is active against penicillin-resistant strains of Staphylococcus aureus and strains resistant to other tetracyclines.

Adult Dose:

• Susceptible infections: 200 mg on day 1 as single or divided doses, then 100 mg once daily for 7-10 days.
• Severe infections: Maintain initial dose throughout treatment.
• STDs (Chlamydia/non-gonococcal urethritis): 100 mg q12hr for 7 days; Syphilis (early): 100 mg BID x 2 weeks; Syphilis (>1 year): 100 mg BID x 4 weeks.
• Acne/Rosacea: 50 mg daily for 6-12 weeks.
• Malaria prophylaxis: 100 mg daily; start 1-2 days before travel and continue for 4 weeks after.
• Cholera: 300 mg single dose.
• Anthrax (post-exposure): 100 mg BID for 60 days.

Child Dose (>8 years, <45 kg): 2-4 mg/kg/day divided q12h.

Common Side Effects:

• Vomiting
• Nausea
• Diarrhea
• Abdominal pain
• Skin rash

Other Side Effects:

• Hemolytic anemia
• Eosinophilia
• Blurred vision
• Dizziness
• Drowsiness

Doxycycline is unsafe during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if benefits outweigh risks.

• Doxycycline cures infection and improves symptoms.
• Take with food and plenty of water to avoid stomach upset.
• Complete the full course of treatment even if you feel better. Stopping early may cause infection to return.
• Take while sitting or standing to prevent throat irritation and do not lie down for 30 minutes.
• Diarrhea may occur as a side effect; inform doctor if it persists or if blood in stools.
• Avoid excessive sun exposure; use sunscreen and protective clothing.
• May cause blurred vision or drowsiness; do not drive if these symptoms occur.
• Do not use in children under 8 years due to risk of permanent tooth discoloration.

Overdose may cause severe nausea, vomiting, diarrhea and allergic reactions. Provide symptomatic treatment.

Store in a cool and dry place, protected from light. Keep out of reach of children.