৳ 130/unit
Pack: ৳ 130
৳ 130/unit
Pack: ৳ 130
At a glance
Ipratropium Bromide is an anticholinergic medicine used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
Indications
- Chronic obstructive pulmonary disease (COPD)
- Asthma (acute and chronic)
Pharmacology
Ipratropium Bromide is a quaternary ammonium compound with anticholinergic properties. It inhibits vagal reflexes by antagonising the action of acetylcholine, preventing increase in intracellular cyclic GMP caused by interaction of acetylcholine with muscarinic receptor on bronchial smooth muscle. It blocks the action of acetylcholine at parasympathetic sites in bronchial smooth muscle causing bronchodilation.
Dosage
Adult Dose (Inhalation):
- Inhaler (MDI): 1-2 puffs (20 mcg/puff) 3-4 times daily; up to 80 mcg may be required
- Nebulizer solution: 250-500 mcg 3-4 times daily; acute bronchospasm: 500 mcg/2 mL
- Maximum 12 puffs in 24 hours
Child Dose (Inhalation):
- MDI (<6 years): 20 mcg tid; (6-12 years): 20-40 mcg tid
- Nebulizer (<6 years, acute asthma): 125-250 mcg, no more often than 6 hourly; (6-12 years): 250 mcg as needed
Side effects
Common Side Effects:
- Dryness in mouth
- Dry nose
- Headache
- Cough
- Throat irritation
- Dizziness
Uncommon: Urticaria, Tachycardia, Skin rash, Pruritus, Vomiting, Anaphylactic reaction, Eye pain, Mydriasis, Increased intraocular pressure, Palpitations, Atrial fibrillation, Nausea
Use in pregnancy
Use in Pregnancy: Generally considered safe; animal studies show low or no adverse effects; limited human studies; benefits must be weighed against possible hazards to fetus.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Ipratropium Bromide does not usually affect your ability to drive
- For inhalation only; do not swallow capsules
- Do not use to relieve sudden breathing problems (use rescue inhaler)
- Take first dose under medical supervision (may cause bronchospasm)
- Caution in narrow-angle glaucoma, prostatic hyperplasia, bladder-outflow obstruction or cystic fibrosis
- Care must be taken not to allow solution or mist to enter eyes during nebulizer therapy
Overdose effects
Overdose: Acute overdosage by inhalation is unlikely (poor systemic absorption); 5 mg inhaled dose causes increased heart rate and palpitation; 30 mg oral dose caused anticholinergic side effects but not severe enough to require specific reversal.
Storage conditions
Do not store above 25°C; keep ampoule in outer carton; use fresh ampoule for each dose.