Ivaten5mg

• Symptomatic treatment of chronic stable angina pectoris (in coronary artery disease patients with normal sinus rhythm)

Adult Dose (Oral):

• Initial: 5 mg twice daily (with meals)
• May be increased after 3-4 weeks to 7.5 mg twice daily, depending on therapeutic response
• 1 tablet in the morning and 1 tablet in the evening during meals
• Heart rate <50 bpm: Reduce dose to 2.5 mg twice daily; if persists, discontinue
• Elderly (≥75 years): Initial: 2.5 mg twice daily

Renal Dose: CrCl >15 mL/min: No dose adjustment; CrCl <15 mL/min: Caution required

Hepatic Impairment: Mild: No dose adjustment; Moderate: Caution; Severe: Contraindicated

Child Dose: Not recommended

Common Side Effects:

• Slow heart rate (bradycardia)
• Headache
• Luminous phenomena (Enhanced brightness)
• High blood pressure
• Visual symptoms (blurred vision)
• 1st degree AV block
• Ventricular extrasystoles
• Dizziness

Precautions:

• Ivabradine may affect your ability to drive (transient luminous phenomena including phosphenes, especially when driving at night)
• May cause dizziness or sleepiness; do not drive or do anything requiring concentration until you know how it affects you
• Temporary changes in vision (enhanced visual brightness) may occur within first 2 months of treatment, gradually resolve
• Monitor blood pressure (may increase)
• Monitor heart rate (low heart rate is common side effect)
• Caution in mild to moderate hypotension, atrial fibrillation, QT syndrome patients