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At a glance

Piracetam is a nootropic medicine used for Alzheimer's disease, stroke, dementia in Parkinson's disease, age-related memory loss, and head injury. It improves communication between nerve cells and protects the brain against oxygen shortage.

Indications
  • Cerebrovascular accidents and cerebral insufficiencies
  • Mental retardation in children
  • Behavior and psychotic problems in old age (memory deficits)
  • Alzheimer's disease
  • Stroke
  • Dementia in Parkinson's disease
  • Age-related memory loss
  • Head injury
Pharmacology

Piracetam is a nootropic that improves cognitive function by enhancing the efficacy of the telencephalon. It modifies neurotransmission, improves neuronal metabolic environment, and enhances microcirculation. It inhibits platelet aggregation and restores erythrocyte deformability, improving flow through the microvasculature.

Dosage

Adult Dose (Oral):

  • Cerebrocortical insufficiency: 800 mg three times daily
  • Cortical myoclonus: 7.2 g daily in 2-3 divided doses, increased by 4.8 g/day every 3-4 days; max 20 g/day
  • Cognitive enhancer: 2.4 g daily in 2-3 divided doses; up to 4.8 g daily in severe cases

Pediatric Dose (Oral):

  • 50 mg/kg body weight in 3 divided doses; reduce by half after desired results

Renal Impairment Dose:

  • CrCl 50-79: 2/3 of usual dose
  • CrCl 30-49: 1/3 of usual dose
  • CrCl 20-29: 1/6 of usual dose
  • CrCl <20: Contraindicated
Side effects

Side Effects:

  • Weight gain
  • Nervousness
  • Agitation
  • Irritability
  • Anxiety
  • Sleep disturbances
  • Fatigue/drowsiness
  • Nausea, vomiting, diarrhea
  • Abdominal pain
  • Vertigo
  • Headache
  • Sexual stimulation (rare)
Use in pregnancy

Use in Pregnancy: Information regarding use during pregnancy is not available; crosses the placenta; not recommended except under exceptional circumstances.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if drowsy or dizzy
  • Inform doctor if bleeding problems or taking blood-thinning medications
  • Caution during pregnancy and lactation
  • Inform doctor if abdominal pain, diarrhea, vomiting occurs
  • Do not stop medication suddenly
Overdose effects

Piracetam appears to be devoid of toxicity even at very high doses; no specific measures needed for overdose.

Storage conditions

Store in a cool and dry place below 30°C, away from sunlight; keep out of reach of children.

Piracetam — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.