৳ 10/unit
Pack: ৳ 10
৳ 10/unit
Pack: ৳ 10
At a glance
Deferiprone is an oral iron chelator used for the treatment of iron overload in patients with thalassemia major when deferoxamine therapy is contraindicated or inadequate.
Indications
- Iron overload in thalassemia major patients when deferoxamine therapy is contraindicated or inadequate
Pharmacology
Deferiprone is a chelating agent with an affinity for ferric ion (iron III). Deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.
Dosage
Adults and children over 6 years: 25 mg/kg three times daily orally (total daily dose 75-99 mg/kg/day). Doses above 100 mg/kg/day are not recommended. Round dose to nearest 250 mg.
Side effects
Common: Fatigue, headache, nausea, vomiting, abdominal pain, joint pain, diarrhea, reddish-brown discoloration of urine.
Serious: Neutropenia, agranulocytosis, increased liver enzymes.
Use in pregnancy
Deferiprone is unsafe during pregnancy as there is definite evidence of risk to the developing baby. May be used in life-threatening situations if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Monitor neutrophil count weekly for neutropenia and agranulocytosis. Seek immediate medical attention if fever, sore throat or flu symptoms occur. Monitor liver and renal function regularly. Avoid use in pregnancy and lactation.
Overdose effects
No adequate information on overdose is available. Overdose may increase side effects. Seek medical attention.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.