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Etoricoxib is a pain relieving medicine. It is used for relieving moderate pain and swelling of joints associated with different forms of gout and arthritis. It is also used for short-term treatment of moderate pain after dental surgery in people 16 years of age and older. Etoricoxib can be taken with or without food. The dose depends on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer than recommended. The most common side effects of this medicine include stomach pain, edema, dizziness, headache, irregular heartbeat, and increased blood pressure. These are not usually serious but if you are worried, ask your doctor about ways of reducing or preventing them. Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine. Heavy drinking can cause excessive drowsiness. Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

• Pain relief

Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.

Adult Dose: Oral Osteoarthritis Adult: 30 mg once daily, increased to 60 mg once daily if needed. Ankylosing spondylitis; Rheumatoid arthritis Adult: 90 mg once daily. Acute gout Adult: 120 mg once daily. Max duration: 8 days. Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily. Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily. Severe (Child-Pugh >10): Avoid. Child Dose: Child: <16 yr Contraindicated.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Etoricoxib may be taken with or without food, but it is better to take it at a fixed time.

Common: • Stomach pain • Diarrhea

[UNSAFE] Etoricoxib may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Etoricoxib helps relieve pain and inflammation. It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen. It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you. Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness. Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment. Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function. Do not take Etoricoxib if you are pregnant, planning to conceive, or breastfeeding.

Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.

May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.

[UNSAFE] It is unsafe to consume alcohol with Etoricoxib.

[CONSULT YOUR DOCTOR] Etoricoxib may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Etoricoxib during breastfeeding is not available. Please consult your doctor.

[CAUTION] Etoricoxib should be used with caution in patients with kidney disease. Dose adjustment of Etoricoxib may be needed. Please consult your doctor. Use of Etoricoxib is not recommended in patients with severe kidney disease. [CAUTION] Etoricoxib should be used with caution in patients with liver disease. Dose adjustment of Etoricoxib may be needed. Please consult your doctor. Use of Etoricoxib is not recommended in patients with severe liver disease.

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