৳ 22/unit
Pack: ৳ 220
৳ 22/unit
Pack: ৳ 220
At a glance
Lacosamide is an antiepileptic medicine used for the treatment of partial-onset seizures and primary generalized tonic-clonic seizures. It selectively enhances slow inactivation of voltage-gated sodium channels, stabilizing hyperexcitable neuronal membranes and inhibiting repetitive neuronal firing.
Indications
- Partial-onset seizures - monotherapy or adjunctive therapy in patients 1 month and older
- Primary generalized tonic-clonic seizures - adjunctive therapy in patients 4 years and older
Pharmacology
Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels, stabilizing hyperexcitable neuronal membranes and inhibiting repetitive neuronal firing. It also binds to CRMP-2, which is involved in neuronal differentiation and axonal outgrowth.
Dosage
Adults (≥17 years):
- Monotherapy: Initial 100 mg twice daily; Maintenance 150-200 mg twice daily
- Adjunctive therapy: Initial 50 mg twice daily; Maintenance 100-200 mg twice daily
- Titrate by 50 mg twice daily every week
Pediatric (Weight-based):
- ≥50 kg: 50 mg twice daily; Maintenance 100-200 mg twice daily
- 30-50 kg: 1 mg/kg twice daily; Maintenance 2-4 mg/kg twice daily
- 6-30 kg: 3-6 mg/kg twice daily
- <6 kg: 3.75-7.5 mg/kg twice daily
Side effects
Common Adverse Reactions:
- Dizziness
- Headache
- Somnolence
- Ataxia
- Tremor
- Nausea
- Vomiting
- Fatigue
- Diplopia
- Blurred vision
Use in pregnancy
Use in Pregnancy: No adequate well-controlled studies; use only if potential benefit justifies potential risk to the fetus.
Precautions & warnings
- Monitor patients for suicidal behavior
- Monitor for dizziness, ataxia, PR interval prolongation, AV block, ventricular tachyarrhythmia, atrial fibrillation, atrial flutter, syncope
- Monitor for multi-organ hypersensitivity
- Use during pregnancy only if potential benefit justifies risk
- Weigh benefits of breastfeeding against unknown risks to the infant
Overdose effects
There is no specific antidote for overdose. General supportive and symptomatic measures should be employed.
Storage conditions
Do not store above 30°C; keep away from light and out of reach of children.