৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Lamivudine is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. It prevents the multiplication of viruses in human cells and helps clear up the infection.
Indications
- HIV infection (in combination with other antiretrovirals)
- Chronic hepatitis B virus (HBV) infection
Pharmacology
Lamivudine is a nucleoside analogue that is phosphorylated intracellularly to its active 5'-triphosphate metabolite. The principal mode of action is inhibition of reverse transcription via DNA chain termination after incorporation of the nucleoside analogue.
Dosage
HIV Infection (Adult):
- 150 mg twice daily or 300 mg once daily (with other antiretrovirals)
Chronic Hepatitis B (Adult):
- 100 mg once daily
- Co-infected patients (HIV+HBV): 300 mg once daily or in 2 divided doses
Children (HIV): 3 mth-12 yr: 4 mg/kg twice daily; Max: 300 mg/day
Children (Hepatitis B): >2 yr: 3 mg/kg once daily; Max: 100 mg/day
Side effects
Common Side Effects:
- Headache
- Runny nose
- Nausea
- Fever
- Diarrhea
- Fatigue
- Abdominal pain
- Skin rash
Use in pregnancy
Use in Pregnancy: Lamivudine may be unsafe during pregnancy. Animal studies have shown harmful effects on the fetus. Consult your doctor.
Precautions & warnings
- Regular blood tests needed to monitor liver function and blood counts
- Caution when driving or doing activities requiring concentration (may cause dizziness or drowsiness)
- Avoid alcohol (may increase liver damage risk)
- If HIV positive, avoid unprotected sex and sharing personal items
- Consult your doctor during pregnancy and lactation
Overdose effects
No specific overdose information available; excessive doses may increase side effects.
Storage conditions
Store in a dry place away from light and heat; keep out of reach of children.