Leukeran2mg
Rx- Generic:
- Chlorambucil
- Company:
- Rainbow Traders
- Dosage form:
- Tablet
- Pack size:
- Box (25 Tablet)
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৳ 45.48/unit
Pack: ৳ 1,137
At a glance
Chlorambucil is an anti-cancer medication used in the treatment of some cancers of the blood and lymphatic system.
Indications
- Hodgkin's Disease
- Non-Hodgkin's Lymphoma
- Chronic Lymphocytic Leukemia
- Waldenstrom's Macroglobulinemia
- Blood cancer
Dosage
Adult Dose:
| Indication | Dose | Schedule |
|---|---|---|
| Chronic Lymphocytic Leukemia | 0.1 mg/kg/day | 3-6 weeks |
| Hodgkin's Lymphoma | 0.2 mg/kg/day | 3-6 weeks |
| Hodgkin's Disease | 200 mcg/kg/day | 4-8 weeks |
| Non-Hodgkin's Lymphoma | 100-200 mcg/kg/day | 4-8 weeks |
| Waldenstrom's Macroglobulinemia | Initial: 6-12 mg/day; Maintenance: 2-8 mg/day | — |
Hepatic Impairment: Primarily metabolized in liver; dose reduction may be required.
Renal Impairment: <1% (including metabolites) excreted in urine; no dose adjustment required.
Side effects
Common Side Effects:
- Anemia (low red blood cell count)
- Decreased blood cells (red cells, white cells, and platelets)
- Decreased white blood cell count (neutrophils)
- Bone marrow suppression
- Nausea
- Vomiting
- Diarrhea
- Mouth ulcer
Rare: Irreversible bone marrow failure, allergic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, seizures, movement disorders, interstitial pulmonary fibrosis, interstitial pneumonia, hepatotoxicity, jaundice, sterile cystitis, drug fever.
Precautions & warnings
- [CONSULT YOUR DOCTOR] It is not known whether Chlorambucil alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
- Chlorambucil should be taken one hour before a meal or two hours after a meal.
- Monitor FBC closely. Bone marrow suppression is reversible only if withdrawn early enough.
- Should not be given to patients who have recently undergone radio- or chemotherapy.
- In lymphocytic infiltration of bone marrow or hypoplastic bone marrow, max daily dose is 0.1 mg/kg.
- Children with nephrotic syndrome, patients on high pulse dosing regimens, history of seizure disorders require caution.
- Ensure adequate contraceptive precautions.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.