Leukin 50
Rx- Generic:
- Mercaptopurine
- Company:
- Beacon Pharmaceuticals PLC
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
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৳ 20/unit
Pack: ৳ 200
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- ৳ 20
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At a glance
Mercaptopurine is an anti-cancer medication used for maintenance therapy of acute lymphoblastic leukemia (ALL). It interferes with DNA and RNA formation in cancer cells to stop their growth and division.
Indications
- Acute lymphoblastic leukemia (ALL) - maintenance therapy (as part of a combination regimen)
- Crohn's disease (off-label)
Dosage
ALL (Adults):
- Induction: 2.5 mg/kg/day (usually 100-200 mg/day)
- Maintenance: 1.5-2.5 mg/kg/day
- Reduce dose by 75% with allopurinol
ALL (Children): 1.25-2.5 mg/kg/day (50-75 mg/m²); Maintenance: 1.5-2.5 mg/kg/day
Crohn's Disease (Adults): Initial 1-1.5 mg/kg/day; max 125 mg/day
Side effects
Common Side Effects:
- Nausea, vomiting
- Skin rash
- Decreased white blood cell count (neutrophils)
- Intestinal ulcer
- Anemia
- Increased bilirubin
- Low blood platelets
- Increased transaminases
- Diarrhea, loss of appetite
Precautions & warnings
- Caution in hepatic and renal dysfunction; monitor hepatic function periodically
- Myelosuppression - monitor blood counts regularly
- TPMT deficiency may cause severe myelotoxicity
- Do not use during pregnancy and lactation
- Caution when driving or doing activities requiring concentration (may cause dizziness)
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.