৳ 1,600/unit
Pack: ৳ 1,600
৳ 1,600/unit
Pack: ৳ 1,600
At a glance
Insulin Detemir is a long-acting human insulin analog used to improve glycemic control in adults and children with diabetes mellitus.
Indications
- Improvement of glycemic control in adults and children with diabetes mellitus
Pharmacology
The primary activity of insulin detemir is the regulation of glucose metabolism. Insulins exert their specific action through binding to insulin receptors. Receptor-bound insulin lowers blood glucose by facilitating cellular uptake of glucose into skeletal muscle and adipose tissue and by inhibiting the output of glucose from the liver. Insulin inhibits lipolysis in the adipocyte, inhibits proteolysis, and enhances protein synthesis.
Dosage
Adult Dose (Subcutaneous):
- Type 1 or 2 Diabetes (once daily): Administer SC with evening meal or at bedtime
- Type 1 or 2 Diabetes (twice daily): Administer SC with morning meal and either with evening meal, at bedtime, or 12 hours after morning dose
- Insulin-naïve Type 2: 10 units/day (or 0.1-0.2 units/kg/day) in evening or divided q12hr
- Conversion from other insulins (glargine or NPH): Unit-to-unit basis; type 2 patients may require more insulin detemir than NPH
- Dose adjustments: Based on blood glucose measurements; look for consistent pattern in blood sugars for >3 days
Child Dose (Type 1, ≥2 years): Approximately one-third of total daily insulin requirements; adolescents <1.2 units/kg/day during growth spurts
Side effects
Side Effects:
- Hypoglycemia
- Lipodystrophy
- Pruritus
- Rash
- Weight gain
- Sodium retention and edema
- Injection site reactions (pain, itching, hives, swelling, inflammation)
- Influenza-like symptoms
- Pallor, Palpitation, Tachycardia, Mental confusion, Weakness, Blurred vision, Itching, Hunger, Nausea
Use in pregnancy
Use in Pregnancy: Category B; generally considered safe; animal studies show low or no adverse effects; limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Caution in renal or hepatic impairment (dosage requirements may be reduced)
- Regular monitoring of blood glucose and HbA1c
- Continuous rotation of injection site within a given area to reduce injection site reactions
- Caution in pregnancy and lactation
- Dose adjustment: Look for consistent pattern in blood sugars for >3 days
- Dosage must be individualized based on clinical response
Overdose effects
Overdose: Excess insulin relative to food intake or energy expenditure may lead to severe and sometimes prolonged life-threatening hypoglycemia; mild episodes treated with oral glucose; severe episodes (coma, seizure, neurologic impairment) treated with IM/SC glucagon or IV glucose.
Storage conditions
Unopened insulin detemir: Store in refrigerator at 2°C-8°C; do not freeze; protect from light; if refrigeration not possible, can be kept at room temperature (below 30°C) for 42 days.