Locular Plus
0.2%+0.5%Rx৳ 110.34/unit
Pack: ৳ 110.34
৳ 110.34/unit
Pack: ৳ 110.34
At a glance
Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye Prep is a combination medication used in the treatment of ocular hypertension and open-angle glaucoma. Brimonidine reduces aqueous humour production and increases uveoscleral outflow, while Timolol reduces aqueous humour formation, together lowering intraocular pressure.
Indications
- Ocular hypertension
- Open-angle glaucoma
Pharmacology
Brimonidine Tartrate is an alpha-2 adrenergic receptor agonist that reduces IOP by decreasing aqueous humour production and increasing uveoscleral outflow. Timolol is a non-selective beta-adrenergic receptor blocker that reduces IOP by decreasing aqueous humour formation.
Dosage
Adults: Instill 1 drop 2 times daily (approximately 12 hours apart).
Note: Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption). Use within 4 weeks of opening.
Side effects
Common side effects: Itching, stinging sensation, foreign body sensation, burning sensation in eye, eye redness, blurred vision, tiredness, drowsiness, headache, dry mouth.
Serious: Allergic reactions, bradycardia, hypotension, respiratory distress (rare).
Avoid driving or operating machinery until you know how this medicine affects you.
Use in pregnancy
May be unsafe during pregnancy (Category C). Limited human studies available; animal studies have shown harmful effects on the developing baby. Your doctor will weigh benefits and risks before prescribing.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause blurred or abnormal vision after use (especially at night or in reduced lighting); do not drive or operate machinery until vision is clear.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption and minimize drug transfer to breast milk).
- Use within 4 weeks of opening the bottle.
- Remove soft contact lenses before use and wait at least 15 minutes before reinserting.
- Do not use in patients receiving MAO inhibitor therapy.
- Caution in patients with severe cardiovascular disease, respiratory disease (asthma, COPD), bradycardia, heart block.
Overdose effects
Overuse may increase systemic absorption, causing bradycardia, hypotension, drowsiness, dry mouth. Consult your doctor if symptoms occur.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children. Use within 4 weeks of opening.