৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Loperamide is used in the treatment of diarrhea. It slows down intestinal contractions, decreasing the speed at which contents pass through, allowing more time for reabsorption of fluids and nutrients, making stools more solid and less frequent.
Indications
- Acute diarrhea
- Chronic diarrhea
- Abdominal cramps associated with diarrhea
- Crohn's disease
- Post-gastric surgery
- Ulcerative colitis
Pharmacology
Loperamide binds to opioid receptors in the gut wall, reducing peristalsis, increasing intestinal transit time, and inhibiting electrolyte and fluid secretion.
Dosage
Acute Diarrhea (Adults):
- Initial: 4 mg, then 2 mg after each loose stool; max 16 mg/day
- Discontinue if no improvement within 48 hours
Children (2-6 years): 1 mg q8hr; (6-8 years): 2 mg q12hr; (8-12 years): 2 mg q8hr
Chronic Diarrhea: 4 mg initially, then 2 mg after each loose stool; maintenance 4-8 mg/day
Side effects
Common Side Effects:
- Constipation
- Nausea
- Headache
- Abdominal pain
- Dry mouth
- Dizziness
- Fatigue
- Skin rash
Use in pregnancy
Use in Pregnancy: Loperamide may be unsafe during pregnancy; animal studies have shown harmful effects on the fetus. Consult your doctor.
Precautions & warnings
- Do not use if blood in stool or severe constipation
- Consult doctor if diarrhea lasts more than 48 hours
- Drink plenty of fluids to prevent dehydration and electrolyte imbalance
- Caution when driving or doing activities requiring concentration (may cause dizziness and sleepiness)
Overdose effects
Overdose may cause constipation, CNS depression, and nausea.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.