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At a glance

Abametapir is a topical pediculicide used for the treatment of head lice infestation in patients 6 months of age and older. It is a metalloproteinase inhibitor that interferes with the development and survival of lice and their eggs.

Indications

Topical treatment of head lice (pediculosis capitis) infestation in patients 6 months of age and older .

Pharmacology

Abametapir is a metalloproteinase inhibitor . Metalloproteinases have a role in physiological processes critical to egg development and survival of lice. By inhibiting this enzyme, abametapir disrupts the life cycle of lice and their eggs .

Dosage

Adults and children ≥6 months:

  • Apply sufficient amount (up to one full bottle) to dry hair and scalp to thoroughly coat the hair and scalp .
  • Leave on for 10 minutes, then rinse thoroughly with warm water .
  • This is a single-application treatment; do not reapply .
Side effects

Common side effects (≥1%):

  • Erythema (redness of skin or scalp) – 4%
  • Skin rash – 3.2%
  • Skin burning sensation – 2.6%
  • Contact dermatitis – 1.7%
  • Vomiting – 1.7%
  • Eye irritation – 1.2%
  • Hair color changes – 1%
  • Scalp pruritus – 1.4%
Use in pregnancy

The safety of abametapir during pregnancy has not been established . Use only if recommended by a physician .

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Risk of Neonatal Benzyl Alcohol Toxicity: This product contains benzyl alcohol, which has been associated with serious and fatal reactions in neonates and low birth-weight infants (“gasping syndrome”) . Use is not recommended in infants under 6 months of age .
  • Risk from Accidental Ingestion: Administer only under direct adult supervision in children .
  • Avoid contact with eyes; rinse with water if accidental contact occurs .
  • If symptoms do not improve within a few days or worsen, consult a doctor .
Overdose effects

If accidentally swallowed, seek immediate medical advice and contact your local Poison Control Center .

Storage conditions

Before and after opening: Store at 2°-8°C in a frost-free place .

Protect from light. Keep out of reach of children .

Abametapir — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.