৳ 150/unit
Pack: ৳ 1,500
৳ 150/unit
Pack: ৳ 1,500
At a glance
Macitentan is used for the long-term treatment of pulmonary arterial hypertension (PAH). It acts as an endothelin receptor antagonist to reduce vasoconstriction and inflammation.
Indications
- Pulmonary arterial hypertension (PAH) - WHO functional class II to III (idiopathic, heritable, connective tissue disease-associated, congenital heart disease-associated)
Pharmacology
Macitentan blocks ETA and ETB receptors to inhibit ET-1-mediated vasoconstriction, fibrosis, proliferation, hypertrophy, and inflammation.
Dosage
Adult Dose (Oral): 10 mg once daily
Side effects
Common Side Effects:
- Nasopharyngitis (14%)
- Headache (13.6%)
- Anemia (13.2%)
Use in pregnancy
Use in Pregnancy: Contraindicated during pregnancy. Verify absence of pregnancy in women of childbearing potential before initiation; monthly pregnancy tests recommended.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Obtain liver enzyme tests prior to initiation
- Not recommended in patients with severe anemia
- Avoid concomitant use with strong CYP3A4 inducers
- Caution with strong CYP3A4 inhibitors
- Contraindicated in pregnancy and lactation
Overdose effects
Overdose may cause headache, nausea, and vomiting; dialysis is unlikely to be effective due to high protein binding.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.