Magnova IV/IM

• Moderate to Severe Pneumonia
• Febrile Neutropenia
• Uncomplicated and Complicated Urinary Tract Infections (including pyelonephritis)
• Uncomplicated Skin and Skin Structure Infections
• Complicated Intra-abdominal Infections (used in combination with metronidazole)

Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs).

Adult Dose (IV):

Pediatric Dose (2 months-16 years):

Renal Dose Adjustment:

Common Side Effects:

• Rash
• Itching
• Nausea
• Vomiting
• Headache
• Fever
• Diarrhea
• Abdominal pain

[SAFE IF PRESCRIBED] Cefepime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. There are no adequate and well-controlled studies of cefepime use in pregnant women. This drug should be used during pregnancy only if clearly needed.

• [CONSULT YOUR DOCTOR] It is not known whether Cefepime alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
• Your doctor has prescribed Cefepime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
• Discontinue Cefepime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
• Avoid consuming alcohol while taking Cefepime as it may cause increased side effects.
• Prescribing Cefepime in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
• As with other antimicrobials, prolonged use of Cefepime may result in overgrowth of non susceptible microorganisms. Repeated evaluation of the patient's condition is essential.
• Many cephalosporins, including cefepime, have been associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy. Prothrombin time should be monitored in patients at risk.
• Cefepime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

Patients who receive an overdose should be carefully observed and given supportive treatment. In the presence of renal insufficiency, hemodialysis, not peritoneal dialysis, is recommended to aid the removal of cefepime from the body. Accidental overdosing has occurred when large doses were given to patients with impaired renal function. Symptoms of overdose include encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor, and coma), myoclonus, seizures, and neuromuscular excitability.

Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician. Keep below 25°C temperature, away from light & moisture.