Manisol 20% IV20%

Mannitol 20% is a medicine used in the treatment of acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain) and to reduce the pressure inside the eyes in a condition called glaucoma. Mannitol 20% works by removing excess water and also relieves inflammation in the affected areas. It may be used alone or in combination with other medicines. It is administered as an injection under the supervision of a medical professional and should not be self administered. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Some common side effects of this medicine include nausea, vomiting, headache, and dehydration. You may also notice some injection site reactions such as pain, redness or swelling. However, these are temporary and usually subside on their own after some time. Please consult your doctor if these do not subside or bother you. Regular monitoring by blood tests may be required while using this medicine. Mannitol 20% is an inert substance with high osmotic pressure. It draws water into the kidney, which in turn increases the amount of urine production. Mannitol 20% is also used to lower the pressure inside the eye or swelling around the brain.

• Acute renal failure • Cerebral edema (accumulation of excessive fluid in the brain) • Glaucoma

Mannitol increases urinary output by inhibiting tubular reabsorption of water and electrolytes. It raises the osmotic pressure of the plasma allowing water to be drawn out of body tissues.

Adult Dose: Intravenous Oliguric phase of renal failure Adult: 50-100 g in a 24-hr period by IV infusion. Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr. Cerebral oedema, Reduction of raised intraocular pressure Adult: 0.25-2 g/kg by IV infusion given over 30-60 minutes. Renal function testing Adult: 0.2 g/kg infused over 3-5 min. Child Dose: Intravenous Edema 0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr Anuria/Oliguria Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g Discontinue if no diuresis within 2 hr

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

If you miss a dose of Mannitol 20%, please consult your doctor.

Common: • Nausea • Vomiting • Headache • Dehydration

[SAFE] Mannitol 20% does not usually affect your ability to drive. It is given as an injection into the veins by a doctor or healthcare professional. Your doctor may get regular blood tests done to monitor sodium and potassium level, kidney function, and lung function while you are taking this medicine. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Pulmonary congestion or oedema; intracranial bleeding; CHF; metabolic oedema with abnormal capillary fragility; anuria due to severe renal disease; severe dehydration.

Increased nephrotoxicity with ciclosporin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Mannitol 20%. Please consult your doctor.

[CONSULT YOUR DOCTOR] Mannitol 20% may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Mannitol 20% is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Mannitol 20% is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Mannitol 20% may not be needed in these patients. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Mannitol 20% in patients with liver disease. Please consult your doctor.

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