osudhkosh

Megacilin4gm+0.5gm/vial

Rx
Dosage form:
Injection
Pack size:
Injection
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৳ 1,003.77/unit

Pack: ৳ 1,003.77

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1003.77
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1000

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At a glance

Piperacillin + Tazobactam is a combination of two antibiotics used for various bacterial infections including intra-abdominal infections, skin and skin structure infections, female pelvic infections, community-acquired pneumonia, and nosocomial pneumonia.

Indications
  • Intra-abdominal infections (appendicitis, peritonitis)
  • Skin and skin structure infections (cellulitis, cutaneous abscess, ischemic/diabetic foot infections)
  • Female pelvic infections (postpartum endometritis, pelvic inflammatory disease)
  • Community-acquired pneumonia
  • Nosocomial pneumonia
Dosage

Adult Dose (Intravenous):

  • Nosocomial pneumonia: 4.5 g every 6 hours (5-14 days), with aminoglycoside
  • Empiric therapy for febrile neutropenia: 4.5 g every 6 hours (5-14 days)
  • Complicated intra-abdominal infections: 4.5 g every 8 hours (5-14 days)
  • Complicated UTI; Skin and soft tissue infections: 4.5 g every 8 hours (5-14 days)
  • Renal impairment (CrCl <20): 2.25 g every 8 hours; (CrCl 20-40): 2.25 g every 6 hours; Hemodialysis: 2.25 g every 12 hours + 0.75 g post-dialysis

Pediatric Dose (Intravenous):

  • 2-12 years (febrile neutropenia): 90 mg/kg every 6 hours (max 4.5 g/dose)
  • 2-12 years (intra-abdominal): 112.5 mg/kg every 8 hours (max 4.5 g/dose)
  • >12 years: Adult dose
Side effects

Side Effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Rash
  • Pruritus
  • Fever
  • Injection site reaction
  • Hypoglycemia
  • Myalgia
  • Arthralgia
  • Insomnia
  • Candidiasis
  • Pseudomembranous colitis
Precautions & warnings
  • Serious hypersensitivity reactions (anaphylactic) may occur; discontinue if reaction occurs
  • Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) may occur; discontinue for progressive rash
  • Hematological effects (bleeding, leukopenia, neutropenia) may occur; monitor during prolonged therapy
  • Nephrotoxicity; consider alternative treatment; monitor renal function
  • Clostridium difficile-associated diarrhea; evaluate if diarrhea occurs
Piperacillin + Tazobactam — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.