At a glance
Thioridazine Hydrochloride is a typical antipsychotic used for schizophrenia. It improves thoughts, mood, and behavior by blocking dopamine receptors in the brain.
Indications
- Schizophrenia
- Depressive disorders
Pharmacology
Thioridazine blocks postsynaptic mesolimbic dopaminergic receptors, reducing dopamine activity in the brain. It exhibits beta-adrenergic blocking and anticholinergic effects, improving both positive and negative symptoms of schizophrenia.
Dosage
Adult Dose (Oral):
- Schizophrenia: Start 50-100 mg three times daily; increase by 100 mg weekly; usual dose 200-800 mg/day in 2-4 divided doses; max 800 mg/day
- Depressive disorders: Start 25 mg three times daily; titrate to 20-200 mg/day
Pediatric Dose (Oral):
- 2-12 years: 0.5 mg/kg/day (divided); increase gradually; max 3 mg/kg/day
- >12 years: Start 50-100 mg every 8 hours; titrate to 200-800 mg/day
Side effects
Common Side Effects:
- Orthostatic hypotension
- Somnolence, dry mouth
- Abnormal voluntary movements
- Weight gain, increased prolactin
- Urinary retention, constipation
- Muscle rigidity, tremor
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Risk of QT prolongation; ECG monitoring required
- Do not use in uncorrected hypokalemia or electrolyte imbalance
- Dizziness on standing; change positions slowly
- May affect driving ability (somnolence, dizziness)
- Regular eye examinations and blood tests required
Overdose effects
Overdose may cause severe extrapyramidal symptoms, QT prolongation, hypotension; provide symptomatic treatment; ECG monitoring.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.