৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Metolazone is a thiazide-like diuretic used to treat hypertension and edema (fluid overload) associated with heart, liver, kidney, or lung disease.
Indications
- Hypertension (high blood pressure)
- Edema (fluid overload) associated with heart failure, liver, kidney, or lung disease
- Edema associated with nephrotic syndrome
- Edema associated with renal disease
Pharmacology
Metolazone is a quinazoline diuretic with properties generally similar to thiazide diuretics. It acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. It does not inhibit carbonic anhydrase.
Dosage
Adult Dose (Oral):
- Hypertension: Initial: 1.25 mg daily; adjusted after 3-4 weeks; Maintenance: 2.5-5 mg daily
- Edema (Heart Failure): 5-10 mg daily; increased if necessary to 20 mg daily; Max: 80 mg in 24 hr
- Edema (Renal Disease): 5-20 mg daily
- Elderly: Initial: 2.5 mg/day or every other day
Child Dose: 0.2-0.4 mg/kg/day (single daily dose or divided q12hr)
Side effects
Common Side Effects:
- Headache
- Nausea
- Increased blood uric acid
- Decreased potassium level in blood
- Glucose intolerance
- Altered blood lipid level
- Dizziness
Serious Side Effects:
- Hyponatremia (sudden drop of sodium level)
- Hypokalemia (potassium loss)
- Hyperuricemia
- Orthostatic hypotension
- Pancreatitis
- Hepatitis
Use in pregnancy
Use in Pregnancy: Generally considered safe. Animal studies show low or no adverse effects on developing baby; limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution while driving (may cause dizziness, blurred vision)
- Take in the morning with breakfast (to avoid nighttime urination)
- Avoid alcohol (may increase dizziness)
- Monitor kidney function and electrolytes regularly
- Monitor blood pressure regularly
- Caution in diabetes, gout, SLE
- Caution in hepatic and renal impairment
Overdose effects
Overdose may cause excessive diuresis, electrolyte disturbances, hypotension. Symptomatic treatment.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.