৳ 64,500/unit
Pack: ৳ 64,500
৳ 64,500/unit
Pack: ৳ 64,500
At a glance
Tenecteplase is a fibrin-specific thrombolytic used for emergency treatment of acute myocardial infarction. It dissolves blood clots by converting plasminogen to plasmin.
Indications
- Acute myocardial infarction (AMI)
Pharmacology
Tenecteplase binds to fibrin-rich clots and converts plasminogen to plasmin. Plasmin degrades the fibrin matrix of the thrombus, dissolving the blood clot and restoring blood flow.
Dosage
Adult Dose (IV):
- Weight <60 kg: 30 mg
- 60-<70 kg: 35 mg
- 70-<80 kg: 40 mg
- 80-<90 kg: 45 mg
- ≥90 kg: 50 mg
- Single IV bolus dose over 5 seconds – as soon as possible after symptom onset
Side effects
Most Common Side Effects:
- Bleeding (most frequent)
- Intracranial hemorrhage (0.9%)
- Hematoma (12.3% minor; 1.7% major)
- Gastrointestinal bleeding (1%)
- Epistaxis (1.5%)
- Nausea, vomiting, hypotension, fever
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in active internal bleeding, recent cerebrovascular accident, intracranial/intraspinal surgery or trauma within 2 months
- Do not use in intracranial neoplasm, AV malformation or aneurysm, bleeding diathesis, severe uncontrolled hypertension
- Minimize arterial and venous punctures
- Discontinue heparin and antiplatelets in serious bleeding
Overdose effects
Overdose increases bleeding risk; in severe prolonged bleeding, consider plasma and platelet replacement.
Storage conditions
Lyophilized: Store below 30°C or at 2-8°C; reconstituted solution should be used immediately; keep out of reach of children.