Metarin plus
500mg+1mgRx৳ 4.02/unit
Pack: ৳ 4.02
৳ 4.02/unit
Pack: ৳ 4.02
At a glance
Metformin Hydrochloride + Rosiglitazone is a combination medicine used to improve glycemic control in type 2 diabetes mellitus. Metformin reduces glucose production and absorption, and Rosiglitazone increases insulin sensitivity.
Indications
- Type 2 diabetes mellitus - as an adjunct to diet and exercise to improve glycemic control
Pharmacology
Metformin reduces glucose production and absorption; Rosiglitazone activates PPARγ receptors to improve insulin sensitivity and glucose/lipid metabolism.
Dosage
Adult Dose (Oral):
- Initial: 2/500 mg once or twice daily
- HbA1c >11% or FPG >270 mg/dL: 500/2 mg twice daily may be considered
- Titrate by 500/2 mg at 2-week intervals; max 2000/8 mg/day
- Switching from metformin monotherapy: Rosiglitazone 4 mg/day + current metformin dose
- Switching from rosiglitazone monotherapy: Metformin 1000 mg/day + current rosiglitazone dose
Side effects
Common Side Effects:
- Nausea
- Loss of appetite
- Taste change
- Abdominal pain
- Diarrhea
- Edema (peripheral edema)
- Weight gain
- Bone fracture
- Blurred vision
- Respiratory tract infection
Use in pregnancy
Use in Pregnancy: Metformin + Rosiglitazone may be unsafe during pregnancy (Category C); animal studies have shown harmful effects on the fetus. Consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Inform doctor if symptoms of lactic acidosis occur (deep/rapid breathing, persistent nausea, vomiting, abdominal pain)
- Monitor blood sugar regularly to avoid hypoglycemia
- Avoid alcohol
- Monitor liver function regularly
- Inform doctor if weight gain, shortness of breath, irregular heartbeat, or abnormal swelling occurs
Overdose effects
Overdose may cause lactic acidosis; symptomatic and supportive treatment; hemodialysis is effective.
Storage conditions
Store in a cool and dry place, away from light and moisture; keep out of reach of children.