Metorax2.5mg

Methotrexate is a medicine used to treat rheumatoid arthritis where it can prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis by killing cells in the skin which are growing too quickly. Methotrexate may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking it too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage. The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, and mouth sores. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. Before taking it, tell your doctor if you are pregnant, have problems related to stomach, liver or kidney or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, x-rays and physical examinations both before and during treatment with this medicine. Methotrexate is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.

• Rheumatoid arthritis • Psoriasis

Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

Adult Dose: Adult: PO Burkitt's lymphoma 10-25 mg/day for 4-8 days, repeat after 7-10 days. Choriocarcinoma 15-30 mg/day for 5 days, repeat after an interval of at least 1 wk for 3-5 courses. Mycosis fungoides 2.5-10 mg/day to induce remission. Rheumatoid arthritis 7.5 mg once wkly, adjust if needed. Up to 20 mg/wk. Crohn's disease 12.5-22.5 mg once wkly for up to 1 yr. PO/IV/IM Psoriasis 10-25 mg once wkly, adjust subsequent doses if needed. IV Osteosarcoma 12-15 g/m2 as infusion, followed by folinic acid. Breast cancer 10-60 mg/m2 often w/ cyclophosphamide and fluorouracil. Advanced lymphosarcoma Up to 30 mg/kg, followed by folinic acid rescue. Acute lymphoblastic leukaemia Maintenance: 2.5 mg/kg every 14 days. PO/IM Acute lymphoblastic leukaemia Maintenance: 15 mg/m2 1-2 times/wk w/ other agents. IM Choriocarcinoma 15-30 mg/day for 5 days. Repeat after at least 1 wk for 3-5 courses. Mycosis fungoides 50 mg/wk in 1-2 divided doses. Crohn's disease 25 mg once wkly for 16 wk. Maintenance: 15 mg/wk. Intrathecal Meningeal leukaemia 12 mg/m2 (Max: 15 mg) once wkly for 2-3 wk, then once mthly. Hepatic impairment Bilirubin 3.1-5.0 mg/dL or AST > 3 times ULN: Give 75% of dose Bilirubin >5.0 mg/dL: Avoid use Child Dose: Polyarticular Juvenile Idiopathic Arthritis Initial: 10 mg/m² PO/IM/SC qWeek Meningeal Leukemia 3 years: 12 mg IT every 2-5 days Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 61-80 75% of dose 51-60 70% of dose 10-50 30-50% of dose <10 Avoid use Intermittent hemodialysis: 50% of dose at normal dosing interval Continuous renal replacement therapy: 50% of dose at normal dosing interval

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methotrexate may be taken with or without food, but it is better to take it at a fixed time.

Common: • Abdominal pain • Indigestion • Loss of appetite • Nausea • Vomiting • Tiredness • Mouth sore

[UNSAFE] Methotrexate may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take it once a week, on the same day every week. Drink plenty of liquids to stay hydrated while taking this medication. Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine. It may take 6 to 8 weeks for Methotrexate to work. Keep taking the medication as prescribed. Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects. It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.

Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver disease, AIDS, pre-existing blood dyscrasias, pregnancy (in patients with psoriasis or rheumatoid arthritis), breast-feeding.

Decreased effectiveness with folic acid and its derivatives. Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some penicillins; aminoglycosides neomycin and paromomycin; sulfonamides such as sulfafurazole and sulfamethoxazole; co-trimoxazole or trimethoprim; nephrotoxic agents (e.g. cisplatin); ciclosporin; etretinate. Synergistic enhancement of effects with fluorouracil. Increased bioavailability of mercaptopurine. Reduces serum-valproate concentrations. Reduced serum concentrations with colestyramine. Increased serum concentrations with omeprazole.

[CAUTION] Caution is advised when consuming alcohol with Methotrexate. Please consult your doctor.

[UNSAFE] Methotrexate is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[UNSAFE] Methotrexate is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Methotrexate should be used with caution in patients with kidney disease. Dose adjustment of Methotrexate may be needed. Please consult your doctor. Regular monitoring of kidney function test is advised while you are taking this medicine. [CAUTION] Methotrexate should be used with caution in patients with liver disease. Dose adjustment of Methotrexate may be needed. Please consult your doctor. Use of Methotrexate is not recommended in patients with severe liver disease.

Suffering from rheumatoid arthritis Now she is medicating with lefno 20 mg n folitrax 20 mg Refer to a Rheumatologist Suffering from rheumatoid arthritis for 2 yrs, feeling pain in left hand ,can&#x27;t move the hand,ecg shows LVH. Take Tab Folitrax 15mg once weekly and Tab Folvite-MR once daily and Tab Saaz-500 twice daily for 1 monthalso consult a Rheumatologist I am Suffering with Psoriasis Disease since 10 years is it safe to use FOLITRAX 7.5Mg & Folvite 5Mg Tablets Yes it is safeBut sometimes it cause sideffect Rhuematiod Arthritis problem having since last 17 years Apply Dynapar QPS spray Take Tab Folitrax 15mg once weekly (every Sunday) and Tab Folvite-MR once daily (Mon to Sat) and Tab Saaz 500 twice daily Hi , I am suffering from rheumatoid arthritis for many many years. I am on Medrol, folitrax, HCQS, lefno and calcium for 10 years. My ESR is always high. Please suggest that is there any alternate line of treatment available. Regards Yes Consult a Rheumatologist for the same I have R/Arthritis disease,once or twice in a week I suffer serious inflatable pain,autoimmumune disease are main in the body,R factor is less no swelling in fingers or body,only few two or three times swelling very less on any one fingers,only stiffness in neck,one side headache,shoulders pain happens twice in a week,after taking zoredol pain relief tablet get relief,also I take Sazo 500mg tab sometimes,whats are the latest medicines for auto immune and body pain.please suggest,thanking you. You have to start Folitrax according to the level of diseaseConsult a rheumatologist for the same Rheumatoid arthritis diseases attack Rheumatoid arthritis diseases tablet for this please consult rheumatologist for the same Deficiency in vit D,arthritis since 8 years,very much in pain,taken 4 capsules a per week,folitrax 5 n gemicol capsule for arthritis Do following investigations and share reports RA factor, ESR, CRP, S.uric acid levelsContinue taking Vitamin-D supplements