৳ 40.27/unit
Pack: ৳ 40.27
৳ 40.27/unit
Pack: ৳ 40.27
At a glance
Clobetasone Butyrate 0.05% Topical is a moderately potent topical corticosteroid used for the treatment of eczema, dermatitis, and other inflammatory skin conditions.
Indications
- Inflammatory skin disorders
- Eczema
- Dermatitis
- Atopic eczema
- Photodermatitis
- Otitis externa
- Primary irritant & allergic dermatitis (napkin rash)
- Prurigo nodularis
- Seborrhoeic dermatitis
- Insect bite reactions
Pharmacology
Clobetasone butyrate is classed as a moderately potent topical corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.
Dosage
Adult Dose (Topical): Use as 0.05% cream or ointment to be applied thinly once or twice daily on affected areas. Should not be used every day for more than 4 weeks at a time.
Side effects
Common Side Effects:
- Local atrophic changes (skin thinning)
- Pigmentation changes
- Hypertrichosis (excessive hair growth)
- Increased liability to infection
- Infections may be masked
- Acute adrenal insufficiency
- Growth retardation in children
- Cushingoid symptoms
- Amenorrhoea
- Hyperhidrosis (excessive sweating)
Use in pregnancy
Safety data on clobetasone in pregnant women is not available. Published data report a significantly increased risk of low birthweight with the use of greater than 300 grams of potent or very potent topical corticosteroid during pregnancy. Pregnancy Category C.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May be absorbed in sufficient amounts to cause systemic effects when applied topically to large areas, broken skin or under occlusive dressings.
- Use with caution in peptic ulcer, osteoporosis, psychoses or severe psychoneuroses.
- Not to be used indiscriminately for pruritus.
- Caution in CHF or hypertension, diabetes mellitus, epilepsy, glaucoma, infectious diseases, ocular herpes simplex, chronic renal failure and uraemia.
- Caution in active or doubtfully quiescent tuberculosis.
- Not for local treatment of eye disorders.
- Avoid prolonged use on the face.
- Caution during pregnancy and lactation.
Overdose effects
Acute overdosage is very unlikely to occur. In the case of chronic overdosage or misuse, features of hypercortisolism may appear; topical steroids should be discontinued gradually.
Storage conditions
Store in a cool and dry place, away from light and out of reach of children.