৳ 8/unit
Pack: ৳ 80
৳ 8/unit
Pack: ৳ 80
At a glance
Propranolol Hydrochloride is a non-cardioselective beta-blocker used for essential hypertension, angina pectoris, cardiac arrhythmia, thyrotoxicosis, anxiety, and prophylaxis of migraine.
Indications
- Essential hypertension
- Angina pectoris
- Cardiac arrhythmia
- Thyrotoxicosis
- Anxiety
- Prophylaxis of migraine
Pharmacology
Propranolol is a non-cardioselective beta-blocker that competitively blocks beta1- and beta2-receptors, decreasing heart rate, myocardial contractility, blood pressure, and myocardial oxygen demand. It has membrane-stabilizing properties and antagonizes the beta-adrenergic stimulating effects of sympathomimetic agents.
Dosage
Adult Dose (Oral):
- Hypertension: 80 mg twice daily initially; 160-320 mg/day maintenance; max 640 mg/day
- Angina pectoris: 40 mg 2-3 times daily initially; 120-240 mg/day maintenance; max 320 mg/day
- Arrhythmia: 30-160 mg/day in divided doses
- Migraine prophylaxis: 40 mg 2-3 times daily initially; 120-240 mg/day maintenance
- Anxiety: 10-40 mg 2-3 times daily
- Hyperthyroidism: 10-40 mg 3-4 times daily
- Severe hepatic impairment: 20 mg three times daily
Pediatric Dose (Oral):
- Hypertension: 1 mg/kg/day in 2 divided doses initially; 2-4 mg/kg/day maintenance; max 4 mg/kg/day
- Arrhythmia/Pheochromocytoma: 0.25-0.5 mg/kg 3-4 times daily
- Migraine prophylaxis: <12 years 10-20 mg 2-3 times daily; >12 years 40 mg 2-3 times daily
Side effects
Common Side Effects:
- Cold extremities
- Lassitude
- Nausea
- Dizziness
- Insomnia
- Paresthesia
- Fatigue
- Weakness
- Arrhythmia
- Raynaud phenomenon
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if dizzy, confused, or tired
- Do not stop abruptly
- Monitor blood sugar in diabetic patients
- Caution in hepatic and renal impairment
- Caution in pregnancy and lactation
Overdose effects
Overdose: Bradycardia, hypotension, heart failure, bronchospasm; treatment: atropine, glucagon, beta-agonists, supportive care.
Storage conditions
Store in a cool and dry place, protected from light.