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At a glance

Milnacipran Hydrochloride is an SNRI drug used for the treatment of fibromyalgia and depression.

Indications
  • Fibromyalgia
  • Depression
Pharmacology

Milnacipran is a potent inhibitor of neuronal norepinephrine and serotonin reuptake in approximately 1:3 ratio.

Dosage

Adult Dose (Oral):

  • Day 1: 12.5 mg once
  • Days 2-3: 25 mg/day (12.5 mg twice daily)
  • Days 4-7: 50 mg/day (25 mg twice daily)
  • After Day 7: 100 mg/day (50 mg twice daily)
  • Maximum Dose: 200 mg/day (100 mg twice daily)

Child Dose: <17 years: Safety and efficacy not established.

Side effects

Common Side Effects:

  • Nausea and vomiting
  • Dizziness
  • Insomnia
  • Constipation
  • Anxiety
  • Decreased appetite
  • Increased sweating
  • Sexual dysfunction
Use in pregnancy

Use in Pregnancy (Category C): Possibly unsafe. Your doctor will weigh benefits and risks.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution while driving (may cause dizziness)
  • Avoid alcohol
  • Do not stop abruptly
  • Inform doctor if suicidal thoughts occur
  • Contraindicated in uncontrolled narrow-angle glaucoma
  • Contraindicated with MAOIs
Overdose effects

Overdose may cause sedation tremor convulsions dyspnea abdominal pain diarrhea fever palpitations hypotension. Supportive treatment.

Storage conditions

Store in a cool and dry place away from light. Keep out of reach of children.

Milnacipran Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.