oshudhkosh

Misotab 200

Rx
Generic:
Misoprostol
Company:
Euro Pharma
Dosage form:
Tablet
Pack size:
Strip (10 Tablet)

৳ 15/unit

Pack: ৳ 150

At a glance

Misoprostol — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Misoprostol is a medicine used for medical abortion (terminating a pregnancy). It is also used for preventing excessive bleeding after delivery. This medicine acts on the uterus and increases its contraction. Misoprostol is given alone or in combination with some other medicine to attain the maximum benefit. It should be taken with food or as your doctor's advice. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24 hours to show its action and you experience bleeding. The most common side effects of this medicine include nausea, Vomiting, Uterine cramps, Diarrhea, Infection following abortion, Uterine bleeding. If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Usually, vaginal bleeding may last for 12 days, inform your doctor if it lasts for more than 12 days or you notice severe abdominal pain. Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using an intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion. Misoprostol increases contractions of the uterus to cause abortion. It can also prevent post-delivery bleeding due to poor contraction of the uterus.

Indications

• Medical abortion • Post-delivery bleeding

Mechanism of action

Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs.

Dosage

Adult Dose: NSAID-Induced Ulcer Adult: Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily (in 2-4 divided doses) with breakfast or main meals and at bedtime; treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required. Prophylaxis of NSAID induced gastric and duodenal ulcer: 200 mcg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy Induction of labor: 100 mcg taken orally. If cervical ripening or active labor does not occur, repeated dose of 100- 200 mcg of oral misoprostol is given every 4 hourly until labor is established (as evidenced by a Bishop score of 7 or more). Maximum number of dose is 6. Termination of pregnancy Day 1: 200 mg of mifepristone PO as a single dose under physician supervision Days 2-3: 800 mcg of misoprostol buccally once as a single dose; must be administered a minimum of 24-hr and a maximum of 48-hr following mifeprostone dose on day 1 Days 7-14 Must return for follow-up visit to confirm complete termination has occurred by medical history, clinical examination, hCG testing, or ultrasonographic scan If complete expulsion has not occurred, but the pregnancy is not ongoing, women may be treated with another dose of misoprostol 800 mcg buccally with follow-up in ~7 days Lack of bleeding following treatment usually indicates failure; however, prolonged or heavy bleeding is not proof of a complete abortion Surgical evacuation is recommended to manage ongoing pregnancies after medical abortion Prevention of postpartum haemorrhage: 600 mcg orally immediately following delivery. Renal Dose: Renal impairment: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Misoprostol is to be taken with food.

Missed dose

If you miss a dose of Misoprostol, it is likely that the termination will not be fully effective. Talk to your doctor if you forget to take Misoprostol.

Side effects

Common: • Menorrhagia (heavy menstrual bleeding) • Vomiting • Nausea • Uterine contractions • Diarrhea • Stomach cramp

Precautions & warnings

[UNSAFE] Misoprostol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Misoprostol helps terminate pregnancy when used along with another medicine called mifepristone. It may also be used to prevent excessive bleeding after delivery. For pregnancy termination: Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness. It does not affect fertility. Use contraception to avoid pregnancy.

Contraindications

Misoprostol is contraindicated to anyone with a history of allergy to prostaglandins. Women of childbearing potential. Pregnancy and lactation.

Drug interactions

May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.

Food interactions

[CAUTION] Caution is advised when consuming alcohol with Misoprostol. Please consult your doctor.

Use in pregnancy

[UNSAFE] Misoprostol is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Use in lactation

[CAUTION] Misoprostol should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

Renal / hepatic impairment

[SAFE IF PRESCRIBED] Misoprostol is safe to use in patients with kidney disease. No dose adjustment of Misoprostol is recommended. However, inform your doctor if you have an underlying kidney disease. This medicine may be started with a low dose and then increased with caution by your doctor. [SAFE IF PRESCRIBED] Misoprostol is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Misoprostol may not be needed in these patients. Please consult your doctor.

Common questions

What is the difference and side effects between misoprost 25 mcg and misoprost 200 mcg There is no difference except in dosage. Both have different uses How to use misoprost and mt pill for miscarriage one month pregnancy Abortion pills can't be prescribed online.please consult a gynecologist. I did medical abortion yesterday I had heavy bleeding and clots . What if the abortion does not take place completely ? In that case you will tend to keep bleeding. Any bleeding for more than 7days must be evaluated I did medical abortion yesterday I had heavy bleeding and clots . What if the abortion does not take place completely ? Wait for a week or 10 days. Generally the bleeding continued for a week. Get an USG done after 2 weeks to check that there is nothing inside the uterus. I had medicinal abortion where my doctor inserted 4 misoprost tablets in my vagina on 10th march and an ultrasound on 20th March showed some blood clots so she inserted another set of 4 misoprost on the same day. Now, since morning i am feeling dizzy, having a headache, weak, palpation, restlessness and increased heart beat. Can it be infection? And should I see a doctor tomorrow or wait for Monday which is my appointment day? Can wait till MondayBut if u are not feeling good go to doctor sos Sir/Mam I am currently going through a medical abortion , my doctor prescribed me to take mifepristone tablet at my home and told me to come after 2 days to clinic for rest of medication , but i have started bleeding after taking the mifepristone alone , should i go and take extra medication or the mifepristone will do it alone? I am having bleeding and pain after 24 hours of taking the mifepristone Yes u should go How can I taKe abortion pills after 3 to 4 days pregnant Hi I have taken 5 tablet still no bleeding only little clot Usually bleeding starts withnin 4-5 hours of taking the last tablet. Since you do not have bleeding, please visit a gynaecologist for a D and C to terminate this pregnancy now. I had undergone medical termination for pregancy on 25-02-2017 .( 7 Weeks medical termination) by tablets. Got heavy bleeding for the past 2 weeks and on 11.03.2017 we had intercourse without any secure and hence i had option 75 tablet within 48 hours. Post that my stomach is feeling painful and cramped. Bleeding started for 2 days and now the flow is light brown colour patch I also taken pregancy test on 20.03.2017 and found the result is positive. we have not taken the scan post the abortion for miscarriage. Also my tummy is bloated and i feel heavy now is dere is any possibily to get pregnant after aborted should i need to take any scan for confirming the pregnancy again. why my stomach is bloated and feeling heavy and having cramp in lower abdomen also have a severe back pain Hi dear. If your pregnancy test is positive then yes you are actually pregnant again. Emergency contraceptives do have a failure rate of 2-3 %. In your case you need to get another scan done to see for the gestational age of the baby and only then proceed for another abortion. Though since you just had an abortion recently, it would be best not to go for medical abortion and opt for surgical evacuation this time to abvoid complications.

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.