Monofocin

• Uncomplicated urinary tract infections (acute cystitis): in women caused by susceptible strains of Escherichia coli and Enterococcus faecalis.

Fosfomycin is a phosphonic acid derivative. It is a synthetic, broad spectrum, bactericidal antibiotic for oral administration. The bactericidal action of Fosfomycin is due to its inactivation of the enzyme enolpyruvyl transferase, thereby irreversibly blocking the condensation of uridine diphosphate N-acetylglucosamine with p-enolpyruvate, one of the first steps in bacterial cell wall synthesis.

Adult Dose (Acute Cystitis):

• Women (18+): 1 sachet (3 g) PO once
• Men (18+): 1 sachet (3 g) every 2-3 days for 3 doses
• Prostatitis: 3 g PO every 3 days for 21 days

Renal Impairment: No dosage adjustment needed.

Children: Should not be used in children.

* Use as directed by the registered physician

Common Side Effects (>1%):

• Diarrhea - 10.4%
• Headache - 10.3%
• Vaginitis - 7.6%
• Nausea - 5.2%
• Rhinitis - 4.5%
• Back pain - 3.0%
• Dysmenorrhea - 2.6%
• Pharyngitis - 2.5%
• Dizziness - 2.3%
• Abdominal pain - 2.2%
• Dyspepsia - 1.8%
• Asthenia - 1.7%
• Rash - 1.4%

Use in Pregnancy: Generally considered safe during pregnancy. Animal studies have shown low or no adverse effects to the developing baby.

Precautions:

• Do not use more than one single dose to treat a single episode of acute cystitis (repeated doses do not improve efficacy, increase adverse events).
• Avoid alcohol and caffeinated drinks, and drink plenty of water.
• Diarrhea is a common side effect - inform your doctor if it does not get better or if you see blood in stools.
• Fosfomycin may cause dizziness or sleepiness - don't drive or do anything requiring concentration.

Overdose: Overdose may cause gastrointestinal disturbances. Gastric lavage and supportive care.

Storage: Store below 25°C, in a dry place, protected from light. Keep out of reach of children.