MSL10mg

• Severe acute and chronic pain
• Pain associated with myocardial infarction
• Unstable angina
• Intractable cough
• Acute pulmonary oedema
• Analgesia during labour
• Post-operative pain

Adult Dose (Oral):

• Moderate-severe pain: 5-20 mg every 4 hours
• Extended-release: 5-20 mg every 12 hours
• Severe pain: 30 mg every 12 hours (retard tablet)
• Post-operative pain: 30 mg every 12 hours for patients >70 kg

Pediatric Dose (Oral):

• 3-5 years: 5 mg every 4 hours
• 6-12 years: 5-10 mg every 4 hours
• 13-18 years: 5-20 mg every 4 hours
• Cancer pain: 0.2-0.8 mg/kg every 12 hours

Parenteral: IM/SC: 5-20 mg; IV: 2.5-10 mg over 4-5 minutes

Common Side Effects (>10%):

• Pruritus (≤80%)
• Urinary retention (15-70%)
• Vomiting (7-70%)
• Constipation (>10%)
• Headache (>10%)
• Somnolence (>10%)

Uncommon (1-10%):

• Abdominal pain, asthenia, backache, depression, diarrhea, dyspnea, fever, insomnia, loss of appetite, nausea, paresthesia, peripheral edema, rash, sweating, xerostomia

Rare: Anaphylaxis, cardiac arrest, circulatory depression, shock, vertigo

• Caution in patients with impaired respiratory function, severe bronchial asthma, convulsive disorders, acute alcoholism, delirium tremens, raised intracranial pressure, hypotension, cardiac arrhythmias, severe cor pulmonale, history of substance abuse
• Dose reduction may be needed in renal and hepatic impairment
• May impair ability to drive or operate machinery
• Long-term use may lead to dependence
• Abrupt cessation may cause withdrawal symptoms