৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Epalrestat is an aldose reductase inhibitor used for the treatment of diabetic nerve pain and numbness caused by diabetic neuropathy.
Indications
- Diabetic Neuropathy: Indicated for the improvement of subjective symptoms (numbness and pain), abnormality of vibration sense and abnormal change in heartbeat associated with diabetic peripheral neuropathy.
Pharmacology
Epalrestat specifically inhibits aldose reductase and accumulation of sorbitol in the nerve; thereby improves subjective symptoms and nerve dysfunction in patients with diabetic peripheral neuropathy.
Dosage
Adult Dose:
- Diabetic Neuropathy: 50 mg three times daily (before meals).
Dose Adjustment: Dosage may be adjusted according to the patient's age and symptoms.
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Abnormal liver function (elevated liver enzymes)
Other Side Effects:
- Malaise
- Headache
- Abdominal pain
- Hypersensitivity reaction
- Thrombocytopenia (rare)
Use in pregnancy
Use in Pregnancy: Information regarding the use of Epalrestat during pregnancy is not available. Should be used only if expected therapeutic benefits outweigh the possible risks. Consult your doctor.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- It is not known whether Epalrestat alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
- Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease.
- If you have existing diabetic nerve disease, wear proper footwear and examine your feet every day to detect lesions early.
- If you have a foot injury or open wound, avoid engaging in weight-bearing activities.
- The administration should be considered to patients showing high glycohemoglobin values even after fundamental therapies for diabetes mellitus.
- When efficacy is not observed even after 12 weeks of administration, other appropriate therapies should be taken.
- In cases of hepatic abnormalities, drug should be discontinued immediately and appropriate measures should be taken.
Overdose effects
Overdose: Limited information is available on overdose. In case of overdose, symptomatic treatment should be given and seek immediate medical attention.
Storage conditions
Storage: Do not store above 30°C. Keep away from light and wet place. Keep out of reach of children.