৳ 4/unit
Pack: ৳ 40
৳ 4/unit
Pack: ৳ 40
At a glance
Thiamine Hydrochloride (Vitamin B1) is an essential water-soluble vitamin used for beriberi, Wernicke's encephalopathy, pregnancy-associated neuritis, and pellagra.
Indications
- Beriberi
- Wernicke's encephalopathy
- Pregnancy-associated neuritis
- Pellagra
- Thiamine deficiency (poor dietary intake, impaired GI absorption, pregnancy, high-carbohydrate diet)
Pharmacology
Thiamine Hydrochloride is absorbed from the GI tract and distributed to most body tissues, with excess excreted in urine. It is converted to thiamine pyrophosphate (TPP), an essential coenzyme in carbohydrate and amino acid metabolism. TPP is vital for pyruvic acid decarboxylation and the citric acid cycle.
Dosage
Adult Dose (Oral/Parenteral):
- Mild chronic deficiency: 10-25 mg/day (single or divided)
- Thiamine deficiency: 100-300 mg/day
- Wernicke-Korsakoff syndrome: Initially 100 mg slow IV over 10 min; then 50-100 mg/day IM/IV until oral intake possible
Pediatric Dose (Oral/Parenteral):
- Thiamine deficiency: 10-50 mg/day (divided)
- Beriberi: 10-25 mg IV/IM/day (critically ill) or 10-50 mg/dose PO/day for ≥2 weeks, then 5-10 mg/day PO for 1 month
Side effects
Side Effects:
- Oral: No adverse effects at therapeutic doses
- IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, throat tightness, angioedema, respiratory distress, cyanosis, pulmonary edema, GI bleeding, transient vasodilation, hypotension
- IM: Tenderness and induration
Use in pregnancy
Use in Pregnancy: Safe during pregnancy; thiamine requirements increase; consult your doctor.
Pregnancy Category: A — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Daily requirements increase during pregnancy and lactation
- Seek immediate medical attention for serious allergic reactions (rash, itching, swelling of face/tongue/throat, difficulty breathing)
Overdose effects
Overdose does not cause toxicity (water-soluble; excess is excreted in urine).
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.