৳ 12.04/unit
Pack: ৳ 12.04
৳ 12.04/unit
Pack: ৳ 12.04
At a glance
Nikethamide is a central and respiratory stimulant used for acute respiratory failure, respiratory depression following anesthesia and CNS depression. It directly stimulates the respiratory center to increase frequency and depth of breathing.
Indications
- Acute respiratory failure
- Respiratory depression following anesthesia
- CNS depression
Pharmacology
Nikethamide directly stimulates the respiratory center and reflexively stimulates it through carotid body chemoreceptors, increasing frequency and depth of breathing.
Dosage
Adult Dose (IV):
- 2-10 mL of 25% solution by slow IV injection, repeated every 20-30 minutes if necessary
Pediatric Dose: Infants and children are particularly susceptible to toxic effects of nikethamide
Side effects
Side Effects:
- Dyspnoea
- Cough, bronchospasm
- Convulsions
- Headache, dizziness
- Alteration of blood pressure
- Cardiac arrhythmia
- Overdose: nausea, vomiting, diarrhoea
Use in pregnancy
Use in Pregnancy: No adequate controlled studies in pregnant women.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Should not be used in less severe degrees of hypertension or impaired cardiac reserve & hepatic dysfunction
- Infants and children are particularly susceptible to toxic effects
Overdose effects
Overdose: Nausea, vomiting, diarrhoea, convulsions; symptomatic treatment.
Storage conditions
Store below 25°C in a dry place, away from light; keep out of reach of children.