৳ 4,500/unit
Pack: ৳ 4,500
৳ 4,500/unit
Pack: ৳ 4,500
At a glance
Remdesivir is an antiviral drug authorized for emergency use in the treatment of COVID-19. It is indicated for hospitalized adult and pediatric patients for whom use of an intravenous agent is clinically appropriate.
Indications
- Suspected or laboratory-confirmed COVID-19 (severe disease: SpO2 <94%, requiring supplemental oxygen, mechanical ventilation, or ECMO)
Pharmacology
Remdesivir is an adenosine nucleotide analog prodrug that is metabolized to the active nucleoside triphosphate in cells. It inhibits SARS-CoV-2 RNA-dependent RNA polymerase, preventing viral RNA replication. It is a weak inhibitor of mammalian DNA and RNA polymerase with low potential for mitochondrial toxicity.
Dosage
Adult Dose (IV):
- With invasive mechanical ventilation/ECMO: Day 1: 200 mg loading; Days 2-10: 100 mg/day (total 10 days)
- Without invasive mechanical ventilation/ECMO: Day 1: 200 mg loading; Days 2-5: 100 mg/day (total 5 days); may extend up to 5 additional days if no clinical improvement (total 10 days)
Pediatric Dose (3.5-<40 kg):
- Loading: 5 mg/kg IV; Maintenance: 2.5 mg/kg/day (total 10 days)
- Without mechanical ventilation/ECMO: 5 days; may extend up to 5 additional days if no improvement
- ≥40 kg: Adult dose
Side effects
Side Effects:
- Increased liver transaminases
Use in pregnancy
Use in Pregnancy: No adequate controlled studies in pregnant women; use only if potential benefit justifies potential risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor liver function tests before and daily during treatment
- Determine eGFR (adults and pediatric >28 days)
- Serious and unexpected adverse events may occur
Overdose effects
No overdose information available; consult your doctor if overused.
Storage conditions
Lyophilized powder: Store at temperature not exceeding 30°C in a dry place; protect from light and moisture; After reconstitution: 4 hours at room temperature or 24 hours at 2-8°C; Diluted solution: 4 hours at room temperature or 24 hours at 2-8°C.