Nobac 400

• Gastrointestinal infections (enteric fever, acute bacterial diarrhea, chronic Salmonella carriers)
• Urinary tract infections (cystitis, pyelonephritis, prostatitis, epididymitis, urethritis)
• Respiratory tract infections (pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis, empyema)
• Ear, nose, and throat infections (otitis media, otitis externa, sinusitis, tonsillitis)
• Bone and joint infections (osteomyelitis, arthritis)
• Skin and soft tissue infections (infected ulcer, wound infection, abscess, cellulitis, erysipelas, infected burn)
• Pelvic infections (salpingitis, endometritis, pelviperitonitis)
• Abdominal and hepatobiliary infections (peritonitis, intra-abdominal abscess, cholangitis, cholecystitis)
• Septicemia, bacteremia, gonorrhea, endocarditis, meningitis

Adult Dose (Oral):

• General infections: 400 mg twice daily (every 12 hours)
• Acute uncomplicated cystitis (female): 800 mg single dose
• Gonococcal urethritis (male): 800 mg single dose (2 tablets)
• Hepatic impairment: Increase dosing intervals in severe hepatic insufficiency

Intravenous Dose:

• 400 mg in 100 or 250 mL of 5% dextrose slow infusion over 1 hour twice daily

Pediatric Dose: Contraindicated in children under 15 years.

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Dyspepsia
• Epigastric pain
• Headache
• Insomnia
• Skin rash
• Pruritus
• Photosensitization
• Myalgia
• Arthralgia
• Tendonitis
• Achilles tendon rupture

• Avoid exposure to sunlight and UV radiation during treatment due to risk of photosensitivity reaction
• Dose readjustment required in severe hepatic insufficiency
• Inform patients of the possibility of Achilles tendon pain
• May affect driving ability
• Dose reduction may be required in kidney disease