৳ 145/unit
Pack: ৳ 145
৳ 145/unit
Pack: ৳ 145
At a glance
Sodium Polystyrene Sulfonate is a cation exchange resin used for the treatment of hyperkalemia (high blood potassium). It exchanges sodium ions for potassium ions in the intestine, eliminating potassium through feces.
Indications
- Hyperkalemia
Pharmacology
Sodium Polystyrene Sulfonate releases sodium ions in the stomach in exchange for hydrogen ions. In the large intestine, hydrogen ions are exchanged for free potassium ions, and the resin is eliminated in feces. This reduces potassium absorption and increases fecal potassium excretion, lowering blood potassium levels.
Dosage
Adult Dose (Oral):
- Average daily dose: 15-60 g (1 sachet 1-4 times daily)
- As suspension in water or syrup: 15 g up to 4 times daily
- Not to be taken with high-potassium fruit juices
Adult (Rectal/Enema):
- 30-50 g resin once or twice daily (6-hour intervals)
- As warm emulsion in 150-200 mL aqueous vehicle
Children and Neonates (Oral/Rectal):
- Acute hyperkalemia: 1 g/kg/day in divided doses
- Maintenance: 0.5 g/kg/day
Side effects
Common Side Effects (1-10%):
- GI disturbance, constipation
- Hypokalemia, hypocalcemia, hypomagnesemia
- Sodium retention, nausea, vomiting
Rare but Serious:
- GI ulceration/necrosis (may lead to perforation)
- Fecal impaction (especially in children)
- Bronchitis/bronchopneumonia (polystyrene particle inhalation)
Use in pregnancy
Use in Pregnancy: No adequate studies; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in renal failure and sodium-restricted conditions (heart failure, severe hypertension)
- Caution with rectal administration in neonates and children
- Monitor for electrolyte disturbances and hypokalemia symptoms
- Discontinue if clinically significant constipation develops
- Irrigate colon after rectal administration to ensure resin removal
Overdose effects
Overdose may cause electrolyte disturbances (hypokalemia, hypocalcemia, hypomagnesemia); symptoms: irritability, confusion, muscle weakness, hyporeflexia, paralysis, apnea; provide symptomatic treatment.
Storage conditions
Store below 30°C; freshly prepare suspension and do not store beyond 24 hours; keep out of reach of children.