NPH(10 mg+3400 Units+10000 Units)/ml
Rx- Company:
- Reman Drug Laboratories Ltd.
- Dosage form:
- Ear Drop
- Pack size:
- 5 ml drop
৳ 60.23/unit
Description
NPH (10 mg+3400 Units+10000 Units)/ml is a ear drop manufactured by Reman Drug Laboratories Ltd. in Bangladesh. Its active ingredient is Hydrocortisone + Neomycin Sulphate + Polymixin B.
Indications
Hydrocortisone, Neomycin Sulphate & Polymixin B ear drops are indicated for the treatment of bacterial ear infections. It will not work for other types of ear infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.
Contraindications
- Contraindicated-
- if you are allergic (hypersensitive) to polymyxin B sulphate, neomycin sulphate, hydrocortisone or any of the other ingredients of this preparation.
- if you are allergic (hypersensitive) to aminoglycoside antibiotics such as framycetin, kanamycin or gentamicin
- if you have a perforated ear drum
- if you have either a viral, fungal or tubercular (TB) infection
- for a child under 3 years old.
Pharmacology
Polymyxin B sulphate and neomycin sulphate belong to a group of medicines called antibiotics. They kill the germs that can cause ear infections. The anti-infective components in the combination are included to provide action against specific organisms susceptible to them. Neomycin sulfate and polymyxin B sulfate together are considered active against the following microorganisms: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. This product does not provide adequate coverage against Serratia marcescens and streptococci, including Streptococcus pneumoniae.
Hydrocortisone belongs to a group of medicines called steroids. It helps to reduce the swelling and irritation caused by the infection. Hydrocortisone suppress the inflammatory response to a variety of agents and they may delay healing. Since Hydrocortisone may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.
Dosage & Administration
- Adults and children over 3 years old: Apply 3 drops into the affected ear up to four times a day, for up to 7 days. Make sure you finish the course of this drop which your doctor has prescribed.
- Administrations-
- Shake the closed bottle gently before each use
- Clean and dry the ears
- Do not use soap, it may stop the medicine working
- Do not put the drops in your eyes.
Interaction
Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. Increased neuromuscular blockade and possibly respiratory depression with neuromuscular blocking agents if significant amounts of neomycin absorbed significantly.
Side Effects
The following side effects rarely may happen with this medicine: seem to get worse instead of better, become red, scaly and itchy.
Pregnancy & Lactation
Do not use this preparation if you are pregnant or plan to get pregnant. Do not breast-feed while using this.
Precautions & Warnings
Caution should be taken if you have kidney problems. If you have a long-standing infection of your outer ear.
Therapeutic Class
Ophthalmic steroid - antibiotic combined preparations, Ophthalmic Steroid preparations
Storage Conditions
Keep out of the reach and sight of children. Do not store above 25°C. Should be stored in the carton to protect it from light.
Disclaimer: This information is for reference only. Always consult a registered physician before taking any medicine.
Price comparison
- This brand
- ৳ 60.23
- Cheapest of this genericPolymix H
- ৳ 50
The cheaper brand costs ৳ 10.23 less per unit
Compared against 1 brands
At a glance
Hydrocortisone + Neomycin Sulphate + Polymixin B ear drops are used for the treatment of bacterial ear infections.
Indications
- Bacterial ear infections (Otitis externa)
- Ocular inflammation with suspected or confirmed bacterial infection
Dosage
Adult Dose (Otic/Aural):
- Neomycin sulfate 3.5 mg (as neomycin base), polymyxin B sulfate 10,000 units, hydrocortisone 10 mg (1%) per ml: Instill 4 drops into affected ear 3-4 times daily
- Instill drop with the affected ear upward and remain in this position for 5 minutes
- Alternatively use a cotton wick
Child Dose (2-16 years):
- Instill 3 drops into affected ear 3-4 times daily
Ophthalmic Dose:
- 1-2 drops every 3-4 hours
Side effects
Rare Side Effects:
- Worsening of infection
- Redness, scaly and itchy
Ophthalmic: Irritation, increased intraocular pressure, glaucoma, posterior subcapsular cataract formation, delayed wound healing, secondary infections
Precautions & warnings
Precautions:
- Caution in kidney problems
- Caution in long-standing infection of outer ear
- Ophthalmic: Monitor intraocular pressure if used for >10 days
- Otic: Limit use to ≤10 days to reduce risk of ototoxicity